Universität zu Köln

Aswendt, Markus ORCID: 0000-0003-1423-0934, Wilhelmsson, Ulrika, Wieters, Frederique, Stokowska, Anna, Schmitt, Felix Johannes ORCID: 0000-0002-5902-9372, Pallast, Niklas, de Pablo, Yolanda ORCID: 0000-0001-5208-2114, Mohammed, Lava, Hoehn, Mathias, Pekna, Marcela ORCID: 0000-0003-2734-8237 and Pekny, Milos (2022). Reactive astrocytes prevent maladaptive plasticity after ischemic stroke. Prog. Neurobiol., 209. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-5118

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Abstract

Restoration of functional connectivity is a major contributor to functional recovery after stroke. We investigated the role of reactive astrocytes in functional connectivity and recovery after photothrombotic stroke in mice with attenuated reactive gliosis (GFAP(-/-)Vim(-/-)). Infarct volume and longitudinal functional connectivity changes were determined by in vivo T2-weighted magnetic resonance imaging (MRI) and resting-state functional MRI. Sensorimotor function was assessed with behavioral tests, and glial and neural plasticity responses were quantified in the peri-infarct region. Four weeks after stroke, GFAP(-/-)Vim(-/-) mice showed impaired recovery of sensorimotor function and aberrant restoration of global neuronal connectivity. These mice also exhibited maladaptive plasticity responses, shown by higher number of lost and newly formed functional connections between primary and secondary targets of cortical stroke regions and increased peri-infarct expression of the axonal plasticity marker Gap43. We conclude that reactive astrocytes modulate recovery-promoting plasticity responses after ischemic stroke.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Aswendt, Markus UNSPECIFIED orcid.org/0000-0003-1423-0934 UNSPECIFIED Wilhelmsson, Ulrika UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieters, Frederique UNSPECIFIED UNSPECIFIED UNSPECIFIED Stokowska, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitt, Felix Johannes UNSPECIFIED orcid.org/0000-0002-5902-9372 UNSPECIFIED Pallast, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED de Pablo, Yolanda UNSPECIFIED orcid.org/0000-0001-5208-2114 UNSPECIFIED Mohammed, Lava UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoehn, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Pekna, Marcela UNSPECIFIED orcid.org/0000-0003-2734-8237 UNSPECIFIED Pekny, Milos UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-683998
DOI:	10.1016/j.pneurobio.2021.102199
Journal or Publication Title:	Prog. Neurobiol.
Volume:	209
Date:	2022
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-5118
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FIBRILLARY ACIDIC PROTEIN; FUNCTIONAL RECOVERY; MICE DEFICIENT; INTERMEDIATE-FILAMENTS; VIMENTIN; GFAP; NEUROGENESIS; CONNECTIVITY; HIPPOCAMPUS; ACTIVATION Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68399