Stegmann, Martin ORCID: 0000-0002-7168-5970, Zecua-Ramirez, Patricia ORCID: 0000-0003-0110-2896, Ludwig, Christina, Lee, Ho-Seok, Peterson, Brenda, Nimchuk, Zachary L., Belkhadir, Youssef ORCID: 0000-0001-7149-7139 and Hueckelhoven, Ralph (2022). RGI-GOLVEN signaling promotes cell surface immune receptor abundance to regulate plant immunity. EMBO Rep., 23 (5). HOBOKEN: WILEY. ISSN 1469-3178

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Abstract

Plant immune responses must be tightly controlled for proper allocation of resources for growth and development. In plants, endogenous signaling peptides regulate developmental and growth-related processes. Recent research indicates that some of these peptides also have regulatory functions in the control of plant immune responses. This classifies these peptides as phytocytokines as they show analogies with metazoan cytokines. However, the mechanistic basis for phytocytokine-mediated regulation of plant immunity remains largely elusive. Here, we identify GOLVEN2 (GLV2) peptides as phytocytokines in Arabidopsis thaliana. GLV2 signaling enhances sensitivity of plants to elicitation with immunogenic bacterial elicitors and contributes to resistance against virulent bacterial pathogens. GLV2 is perceived by ROOT MERISTEM GROWTH FACTOR 1 INSENSITIVE (RGI) receptors. RGI mutants show reduced elicitor sensitivity and enhanced susceptibility to bacterial infection. RGI3 forms ligand-induced complexes with the pattern recognition receptor (PRR) FLAGELLIN SENSITIVE 2 (FLS2), suggesting that RGIs are part of PRR signaling platforms. GLV2-RGI signaling promotes PRR abundance independent of transcriptional regulation and controls plant immunity via a previously undescribed mechanism of phytocytokine activity.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Stegmann, MartinUNSPECIFIEDorcid.org/0000-0002-7168-5970UNSPECIFIED
Zecua-Ramirez, PatriciaUNSPECIFIEDorcid.org/0000-0003-0110-2896UNSPECIFIED
Ludwig, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Ho-SeokUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peterson, BrendaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nimchuk, Zachary L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Belkhadir, YoussefUNSPECIFIEDorcid.org/0000-0001-7149-7139UNSPECIFIED
Hueckelhoven, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-684784
DOI: 10.15252/embr.202153281
Journal or Publication Title: EMBO Rep.
Volume: 23
Number: 5
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1469-3178
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INNATE IMMUNITY; LATERAL ROOT; ELICITOR PEPTIDES; SECRETED PEPTIDE; QUALITY-CONTROL; GROWTH-FACTOR; ARABIDOPSIS; PATTERN; FLS2; PERCEPTIONMultiple languages
Biochemistry & Molecular Biology; Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/68478

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