Universität zu Köln

Johansson, Madeleine ORCID: 0000-0001-9057-9148, Fedorowski, Artur ORCID: 0000-0002-5352-6327, Jordan, Jens ORCID: 0000-0003-4518-0706, Engstrom, Gunnar ORCID: 0000-0002-8618-9152, Nilsson, Peter M. and Hamrefors, Viktor (2023). Orthostatic blood pressure adaptations, aortic stiffness, and central hemodynamics in the general population: insights from the Malmo Offspring Study (MOS). Clin. Auton. Res., 33 (1). S. 29 - 41. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1619-1560

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Abstract

PurposeArterial stiffness is independently associated with orthostatic hypotension in older individuals. The relationship between orthostatic blood pressure adaptation and aortic stiffness has not been thoroughly examined in a younger population. We investigated the relationship between orthostatic blood pressure adaptations, central aortic hemodynamics, and aortic stiffness in a cohort of predominantly younger and middle-aged adults. MethodsWe analyzed an observational, population-based study of 5259 individuals living in Malmo, Sweden. We related aortic stiffness and central hemodynamics assessed by carotid-femoral pulse wave velocity and pulse wave analysis at the arteria radialis using Sphygmocor to orthostatic blood pressure adaptation after 3 min standing. ResultsThe mean age of the population was 41.9 & PLUSMN; 14.5 years, and 52.1% were women. We observed the highest aortic stiffness and central aortic blood pressure measurements in the lowest and highest quartiles of orthostatic systolic blood pressure differences (p < 0.001). Aortic stiffness and central aortic blood pressure gradually decreased across increasing quartiles of orthostatic diastolic blood pressure difference (p < 0.001). After full adjustment, orthostatic diastolic blood pressure remained significantly associated with aortic stiffness (p = 0.001) and central aortic blood pressure (p < 0.001), whereas orthostatic systolic blood pressure was significantly associated only with central aortic systolic blood pressure (p = 0.009). No significant associations were found between subclinical orthostatic hypotension, aortic stiffness, and central hemodynamics. ConclusionsOur findings demonstrate that altered blood pressure responses to orthostatic challenges, both blood pressure reductions and blood pressure increases, are independently and inversely associated with markers of aortic stiffness (vascular aging) in a predominantly young to middle-aged population.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Johansson, Madeleine UNSPECIFIED orcid.org/0000-0001-9057-9148 UNSPECIFIED Fedorowski, Artur UNSPECIFIED orcid.org/0000-0002-5352-6327 UNSPECIFIED Jordan, Jens UNSPECIFIED orcid.org/0000-0003-4518-0706 UNSPECIFIED Engstrom, Gunnar UNSPECIFIED orcid.org/0000-0002-8618-9152 UNSPECIFIED Nilsson, Peter M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamrefors, Viktor UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-684793
DOI:	10.1007/s10286-022-00911-z
Journal or Publication Title:	Clin. Auton. Res.
Volume:	33
Number:	1
Page Range:	S. 29 - 41
Date:	2023
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1619-1560
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PULSE-WAVE VELOCITY; ALL-CAUSE MORTALITY; ARTERIAL STIFFNESS; BAROREFLEX SENSITIVITY; CARDIOVASCULAR EVENTS; HYPOTENSION; RISK; PREDICTION; ADULTS Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68479