Universität zu Köln

Pirosa, Maria Cristina, Borchmann, Sven, Jardin, Fabrice, Gaidano, Gianluca and Rossi, Davide (2022). Controversies in the Interpretation of Liquid Biopsy Data in Lymphoma. Hemasphere, 6 (6). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 2572-9241

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Abstract

The rapid evolution of genomic technologies over the last years has led to the development of different methods for the detection, measurement and analysis of cell-free DNA fragments (cfDNA) which are shed into the bloodstream by apoptotic cells and circulate at a low concentration in plasma. In cancer patients, the proportion of tumor-derived cfDNA is defined as circulating tumor DNA. This analysis, commonly known as liquid biopsy, allows to access tumor DNA through a simple blood sampling and therefore without the need of an invasive tissue biopsy. For this reason, this tool may have several clinical applications in terms of diagnosis, prognosis, and monitoring of minimal residual disease. However, there are still several critical issues that need to be resolved. In this review, we will discuss some of the controversies around this method and its potential clinical applications.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pirosa, Maria Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Jardin, Fabrice UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaidano, Gianluca UNSPECIFIED UNSPECIFIED UNSPECIFIED Rossi, Davide UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-685507
DOI:	10.1097/HS9.0000000000000727
Journal or Publication Title:	Hemasphere
Volume:	6
Number:	6
Date:	2022
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	2572-9241
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CIRCULATING TUMOR DNA; B-CELL LYMPHOMA; CENTRAL-NERVOUS-SYSTEM; LUNG-CANCER; RESIDUAL DISEASE; PROGNOSTIC VALUE; MYD88 MUTATIONS; HETEROGENEITY; MANAGEMENT; RECURRENT Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68550