Universität zu Köln

Fedorova, Tatyana D., Knudsen, Karoline, Andersen, Katrine B., Horsager, Jacob ORCID: 0000-0001-6098-0045, Skjaerbaek, Casper ORCID: 0000-0003-2823-8785, Beier, Christoph P., Sommerauer, Michael, Svendsen, Kristina B., Otto, Marit and Borghammer, Per ORCID: 0000-0001-6391-8052 (2022). Imaging progressive peripheral and central dysfunction in isolated REM sleep behaviour disorder after 3 years of follow-up. Parkinsonism Relat. Disord., 101. S. 99 - 105. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Introduction: Most patients with isolated rapid eye movement sleep behaviour disorder (iRBD) convert to Parkinson's disease (PD), dementia with Lewy bodies, or multiple system atrophy within 15 years of diagnosis. Furthermore, iRBD patients develop non-motor symptoms similar to those of manifest PD patients and display dysfunction of the sympathetic and parasympathetic nervous system, comparable to that seen in PD. However, progression rates of autonomic dysfunction in iRBD have not been studied with objective measures in detail, which is the aim of this study. Methods: Twenty-two iRBD patients were included at baseline and 14 participated in follow-up after 3 years. Colonic transit time (CTT) was examined using radio opaque markers, colonic volume was defined on abdominal computed tomography (CT) scans, Iodine-123-metaiodobenzylguanidine ([123I]MIBG) scintigraphy was performed to assess cardiac sympathetic innervation, and 3,4-dihydroxy-6-(18F) fluoro-L-phenylalanine ([18F]FDOPA) positron emission tomography (PET) scan determined nigrostriatal dopamine storage capacity. All examinations were performed at baseline and after 3 years. Results: iRBD patients displayed increased CTT (p = 0.001) and colonic volume (p = 0.01) at follow-up compared to baseline. Furthermore, [123I]MIBG uptake and [18F]FDOPA uptake showed progressive reductions at follow-up (p = 0.02 and p = 0.002, respectively). No correlations were seen between changes in intestinal or cardiac measurements and dopaminergic function. Conclusion: Using objective markers, the present study documented that intestinal dysfunction and cardiac sympathetic degeneration worsen in the majority of iRBD patients over a 3-year period. The absent correlation between these markers and nigrostriatal dopaminergic dysfunction suggests that progressive gastrointestinal and cardiac dysfunction in iRBD is caused mainly by non-dopaminergic mechanisms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fedorova, Tatyana D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Knudsen, Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Andersen, Katrine B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Horsager, Jacob UNSPECIFIED orcid.org/0000-0001-6098-0045 UNSPECIFIED Skjaerbaek, Casper UNSPECIFIED orcid.org/0000-0003-2823-8785 UNSPECIFIED Beier, Christoph P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommerauer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Svendsen, Kristina B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Otto, Marit UNSPECIFIED UNSPECIFIED UNSPECIFIED Borghammer, Per UNSPECIFIED orcid.org/0000-0001-6391-8052 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-685577
DOI:	10.1016/j.parkreldis.2022.07.005
Journal or Publication Title:	Parkinsonism Relat. Disord.
Volume:	101
Page Range:	S. 99 - 105
Date:	2022
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1873-5126
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PARKINSONS-DISEASE; MODEL Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68557