Universität zu Köln

Vujovic, Nina, Piron, Matthew J., Qian, Jingyi, Chellappa, Sarah L. ORCID: 0000-0002-6190-464X, Nedeltcheva, Arlet, Barr, David, Heng, Su Wei, Kerlin, Kayla, Srivastav, Suhina, Wang, Wei, Shoji, Brent, Garaulet, Marta ORCID: 0000-0002-4066-3509, Brady, Matthew J. and Scheer, Frank A. J. L. (2022). Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity. Cell Metab., 34 (10). S. 1486 - 1507. CAMBRIDGE: CELL PRESS. ISSN 1932-7420

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Abstract

Late eating has been linked to obesity risk. It is unclear whether this is caused by changes in hunger and appe-tite, energy expenditure, or both, and whether molecular pathways in adipose tissues are involved. Therefore, we conducted a randomized, controlled, crossover trial (ClinicalTrials.gov NCT02298790) to determine the ef-fects of late versus early eating while rigorously controlling for nutrient intake, physical activity, sleep, and light exposure. Late eating increased hunger (p < 0.0001) and altered appetite-regulating hormones, increasing waketime and 24-h ghrelin:leptin ratio (p < 0.0001 and p = 0.006, respectively). Furthermore, late eating decreased waketime energy expenditure (p = 0.002) and 24-h core body temperature (p = 0.019). Adipose tis-sue gene expression analyses showed that late eating altered pathways involved in lipid metabolism, e.g., p38 MAPK signaling, TGF-b signaling, modulation of receptor tyrosine kinases, and autophagy, in a direction consistent with decreased lipolysis/increased adipogenesis. These findings show converging mechanisms by which late eating may result in positive energy balance and increased obesity risk.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vujovic, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Piron, Matthew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Qian, Jingyi UNSPECIFIED UNSPECIFIED UNSPECIFIED Chellappa, Sarah L. UNSPECIFIED orcid.org/0000-0002-6190-464X UNSPECIFIED Nedeltcheva, Arlet UNSPECIFIED UNSPECIFIED UNSPECIFIED Barr, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Heng, Su Wei UNSPECIFIED UNSPECIFIED UNSPECIFIED Kerlin, Kayla UNSPECIFIED UNSPECIFIED UNSPECIFIED Srivastav, Suhina UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Wei UNSPECIFIED UNSPECIFIED UNSPECIFIED Shoji, Brent UNSPECIFIED UNSPECIFIED UNSPECIFIED Garaulet, Marta UNSPECIFIED orcid.org/0000-0002-4066-3509 UNSPECIFIED Brady, Matthew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheer, Frank A. J. L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-685684
DOI:	10.1016/j.cmet.2022.09.007
Journal or Publication Title:	Cell Metab.
Volume:	34
Number:	10
Page Range:	S. 1486 - 1507
Date:	2022
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1932-7420
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIET-INDUCED THERMOGENESIS; FOOD-INTAKE; WEIGHT-LOSS; WORLDWIDE PREVALENCE; APPETITE SENSATIONS; SUBSTRATE OXIDATION; SLEEP CURTAILMENT; CALORIC-INTAKE; BREAKFAST; IMPACT Multiple languages Cell Biology; Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68568