Universität zu Köln

Srinivasan, Sureshkumar Perumal, Nemade, Harshal ORCID: 0000-0002-2704-181X, Cherianidou, Anna, Peng, Luying, Cruz-Molina, Sara, Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 and Sachinidis, Agapios (2022). Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells. Cell Death Discov., 8 (1). LONDON: SPRINGERNATURE. ISSN 2058-7716

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Abstract

Significant evidence points to Strip2 being a key regulator of the differentiation processes of pluripotent embryonic stem cells. However, Strip2 mediated epigenetic regulation of embryonic differentiation and development is quite unknown. Here, we identified several interaction partners of Strip2, importantly the co-repressor molecular protein complex nucleosome remodeling deacetylase/Tripartite motif-containing 28/Histone deacetylases/Histone-lysine N-methyltransferase SETDB1 (NuRD/TRIM28/HDACs/SETDB1) histone methyltransferase, which is primarily involved in regulation of the pluripotency of embryonic stem cells and its differentiation. The complex is normally activated by binding of Krueppel-associated box zinc-finger proteins (KRAB-ZFPs) to specific DNA motifs, causing methylation of H3 to Lysin-9 residues (H3K9). Our data showed that Strip2 binds to a DNA motif (20 base pairs), like the KRAB-ZFPs. We establish that Strip2 is an epigenetic regulator of pluripotency and differentiation by modulating DNA KRAB-ZFPs as well as the NuRD/TRIM28/HDACs/SETDB1 histone methyltransferase complex.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Srinivasan, Sureshkumar Perumal UNSPECIFIED UNSPECIFIED UNSPECIFIED Nemade, Harshal UNSPECIFIED orcid.org/0000-0002-2704-181X UNSPECIFIED Cherianidou, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Peng, Luying UNSPECIFIED UNSPECIFIED UNSPECIFIED Cruz-Molina, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Rada-Iglesias, Alvaro UNSPECIFIED orcid.org/0000-0001-7137-1341 UNSPECIFIED Sachinidis, Agapios UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-685727
DOI:	10.1038/s41420-022-01237-5
Journal or Publication Title:	Cell Death Discov.
Volume:	8
Number:	1
Date:	2022
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	2058-7716
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ZINC-FINGER PROTEIN; GENE-EXPRESSION; DNA METHYLATION; HISTONE H3; KRAB; MAINTENANCE; REPRESSION; CHROMATIN Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68572