Universität zu Köln

Johanndrees, Oliver ORCID: 0000-0001-6659-3951, Baggs, Erin L., Uhlmann, Charles ORCID: 0000-0002-6749-4805, Locci, Federica, Laessle, Henriette L., Melkonian, Katharina, Kaeufer, Kiara, Dongus, Joram A., Nakagami, Hirofumi, Krasileva, Ksenia, V, Parker, Jane E. and Lapin, Dmitry ORCID: 0000-0001-9591-3950 (2023). Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1. Plant Physiol., 191 (1). S. 626 - 643. CARY: OXFORD UNIV PRESS INC. ISSN 1532-2548

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Abstract

Plant Toll/Interleukin-1 receptor domain proteins can use different mechanisms to induce cell death. Toll/Interleukin-1 receptor (TIR) domains are integral to immune systems across all kingdoms. In plants, TIRs are present in nucleotide-binding leucine-rich repeat (NLR) immune receptors, NLR-like, and TIR-only proteins. Although TIR-NLR and TIR signaling in plants require the ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1) protein family, TIRs persist in species that have no EDS1 members. To assess whether particular TIR groups evolved with EDS1, we searched for TIR-EDS1 co-occurrence patterns. Using a large-scale phylogenetic analysis of TIR domains from 39 algal and land plant species, we identified 4 TIR families that are shared by several plant orders. One group occurred in TIR-NLRs of eudicots and another in TIR-NLRs across eudicots and magnoliids. Two further groups were more widespread. A conserved TIR-only group co-occurred with EDS1 and members of this group elicit EDS1-dependent cell death. In contrast, a maize (Zea mays) representative of TIR proteins with tetratricopeptide repeats was also present in species without EDS1 and induced EDS1-independent cell death. Our data provide a phylogeny-based plant TIR classification and identify TIRs that appear to have evolved with and are dependent on EDS1, while others have EDS1-independent activity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Johanndrees, Oliver UNSPECIFIED orcid.org/0000-0001-6659-3951 UNSPECIFIED Baggs, Erin L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Uhlmann, Charles UNSPECIFIED orcid.org/0000-0002-6749-4805 UNSPECIFIED Locci, Federica UNSPECIFIED UNSPECIFIED UNSPECIFIED Laessle, Henriette L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Melkonian, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaeufer, Kiara UNSPECIFIED UNSPECIFIED UNSPECIFIED Dongus, Joram A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nakagami, Hirofumi UNSPECIFIED UNSPECIFIED UNSPECIFIED Krasileva, Ksenia, V UNSPECIFIED UNSPECIFIED UNSPECIFIED Parker, Jane E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lapin, Dmitry UNSPECIFIED orcid.org/0000-0001-9591-3950 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-686937
DOI:	10.1093/plphys/kiac480
Journal or Publication Title:	Plant Physiol.
Volume:	191
Number:	1
Page Range:	S. 626 - 643
Date:	2023
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1532-2548
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NAD(+) CLEAVAGE ACTIVITY; CELL-DEATH; TIR DOMAINS; RESISTANCE PROTEIN; PATHOGEN EFFECTOR; SELF-ASSOCIATION; STRUCTURAL BASIS; EVOLUTION; DEFENSE; FAMILY Multiple languages Plant Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68693