Universität zu Köln

von Eugen, Kaya, Endepols, Heike, Drzezga, Alexander, Neumaier, Bernd, Gunturkun, Onur ORCID: 0000-0003-4173-5233, Backes, Heiko and Strockens, Felix ORCID: 0000-0002-1522-7297 (2022). Avian neurons consume three times less glucose than mammalian neurons. Curr. Biol., 32 (19). S. 4306 - 4319. CAMBRIDGE: CELL PRESS. ISSN 1879-0445

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Abstract

Brains are among the most energetically costly tissues in the mammalian body.(1) This is predominantly caused by expensive neurons with high glucose demands.(2) Across mammals, the neuronal energy budget appears to be fixed, possibly posing an evolutionary constraint on brain growth.(3-6) Compared to similarly sized mammals, birds have higher numbers of neurons, and this advantage conceivably contributes to their cognitive prowess.(7) We set out to determine the neuronal energy budget of birds to elucidate how they can metabolically support such high numbers of neurons. We estimated glucose metabolism using positron emission tomography (PET) and 2-[18F]fluoro-2-deoxyglucose ([F-18]FDG) as the radiotracer in awake and anesthetized pigeons. Combined with kinetic modeling, this is the gold standard to quantify cerebral metabolic rate of glucose consumption (CMRglc).(8) We found that neural tissue in the pigeon consumes 27.29 +/- 1.57 mmol glucose per 100 g per min in an awake state, which translates into a surprisingly low neuronal energy budget of 1.86 x 10(-9) +/- 0.2 x 10(-9) mmol glucose per neuron per minute. This is approximately 3 times lower than the rate in the average mammalian neuron.(3) The remarkably low neuronal energy budget explains how pigeons, and possibly other avian species, can support such high numbers of neurons without associated metabolic costs or compromising neuronal signaling. The advantage in neuronal processing of information at a higher efficiency possibly emerged during the distinct evolution of the avian brain.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Eugen, Kaya UNSPECIFIED UNSPECIFIED UNSPECIFIED Endepols, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumaier, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Gunturkun, Onur UNSPECIFIED orcid.org/0000-0003-4173-5233 UNSPECIFIED Backes, Heiko UNSPECIFIED UNSPECIFIED UNSPECIFIED Strockens, Felix UNSPECIFIED orcid.org/0000-0002-1522-7297 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-688128
DOI:	10.1016/j.cub.2022.07.070
Journal or Publication Title:	Curr. Biol.
Volume:	32
Number:	19
Page Range:	S. 4306 - 4319
Date:	2022
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1879-0445
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FDG LUMPED CONSTANT; RAT-BRAIN; PET; METABOLISM; TEMPERATURE; QUANTIFICATION; VERTEBRATES; INTEGRATION; EVOLUTION; PRIMATE Multiple languages Biochemistry & Molecular Biology; Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68812