Universität zu Köln

Qian, Pingping, Song, Wen ORCID: 0000-0002-9498-2409, Zaizen-Iida, Miki, Kume, Sawa, Wang, Guodong, Zhang, Ye, Kinoshita-Tsujimura, Kaori, Chai, Jijie and Kakimoto, Tatsuo ORCID: 0000-0002-5602-2730 (2022). A Dof-CLE circuit controls phloem organization. Nat. Plants, 8 (7). S. 817 - 843. BERLIN: NATURE PORTFOLIO. ISSN 2055-0278

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Abstract

This study shows that Dof transcription factors in the phloem precursors not only induce formation of phloem, but also cause secretion of CLE peptides, which in turn inhibit phloem formation in neighbourhing cells by post-transcriptionally decreasing Dofs. The phloem consists of sieve elements (SEs) and companion cells (CCs). Here we show that Dof-class transcription factors preferentially expressed in the phloem (phloem-Dofs) are not only necessary and sufficient for SE and CC differentiation, but also induce negative regulators of phloem development, CLAVATA3/EMBRYO SURROUNDING REGION-RELATED25 (CLE25), CLE26 and CLE45 secretory peptides. CLEs were perceived by BARELY ANY MERISTEM (BAM)-class receptors and CLAVATA3 INSENSITIVE RECEPTOR KINASE (CIK) co-receptors, and post-transcriptionally decreased phloem-Dof proteins and repressed SE and CC formation. Multiple mutations in CLE-, BAM- or CIK-class genes caused ectopic formation of SEs and CCs, producing an SE/CC cluster at each phloem region. We propose that while phloem-Dofs induce phloem cell formation, they inhibit excess phloem cell formation by inducing CLEs. Normal-positioned SE and CC precursor cells appear to overcome the effect of CLEs by reinforcing the production of phloem-Dofs through a positive feedback transcriptional regulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Qian, Pingping UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Wen UNSPECIFIED orcid.org/0000-0002-9498-2409 UNSPECIFIED Zaizen-Iida, Miki UNSPECIFIED UNSPECIFIED UNSPECIFIED Kume, Sawa UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Guodong UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Ye UNSPECIFIED UNSPECIFIED UNSPECIFIED Kinoshita-Tsujimura, Kaori UNSPECIFIED UNSPECIFIED UNSPECIFIED Chai, Jijie UNSPECIFIED UNSPECIFIED UNSPECIFIED Kakimoto, Tatsuo UNSPECIFIED orcid.org/0000-0002-5602-2730 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-688135
DOI:	10.1038/s41477-022-01176-0
Journal or Publication Title:	Nat. Plants
Volume:	8
Number:	7
Page Range:	S. 817 - 843
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2055-0278
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL FATE; PROTOPHLOEM DIFFERENTIATION; GENETIC NETWORKS; TARGET GENES; ARABIDOPSIS; PROTEIN; GROWTH; EXPRESSION; REQUIRES; PERCEPTION Multiple languages Plant Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68813