Universität zu Köln

Schild, Ann-Katrin ORCID: 0000-0002-1920-0198, Goereci, Yasemin, Scharfenberg, Daniel ORCID: 0000-0003-2781-3143, Klein, Kim, Luelling, Joachim, Meiberth, Dix, Schweitzer, Finja, Stuermer, Sophie, Zeyen, Philip, Sahin, Derya ORCID: 0000-0002-0573-0526, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Jessen, Frank, Franke, Christiana, Onur, Oezguer A., Kessler, Josef, Warnke, Clemens ORCID: 0000-0002-3510-9255 and Maier, Franziska ORCID: 0000-0002-9335-9594 (2023). Multidomain cognitive impairment in non-hospitalized patients with the post-COVID-19 syndrome: results from a prospective monocentric cohort. J. Neurol., 270 (3). S. 1215 - 1224. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

Full text not available from this repository.

Abstract

Background A fraction of patients with asymptomatic to mild/moderate acute COVID-19 disease report cognitive deficits as part of the post-COVID-19 syndrome. This study aimed to assess the neuropsychological profile of these patients. Methods Assessment at baseline (three months or more following acute COVID-19) of a monocentric prospective cohort of patients with post-COVID-19 syndrome. Multidomain neuropsychological tests were performed, and questionnaires on depression, anxiety, fatigue, sleep, and general health status were administered. Results Of the 58 patients screened, six were excluded due to possible alternative causes of cognitive impairment (major depression, neurodegenerative disease). Of the remaining 52 individuals, only one had a below-threshold screening result on Mini-Mental State Examination, and 13 scored below the cut-off on Montreal Cognitive Assessment. Extended neuropsychological testing revealed a neurocognitive disorder (NCD) in 31 (59.6%) participants with minor NCD in the majority of cases (n = 26). In patients with NCD, the cognitive domains learning/memory and executive functions were impaired in 60.7%, complex attention in 51.6%, language in 35.5%, and perceptual-motor function in 29.0%. Cognitive profiles were associated with daytime sleepiness but not with depression, anxiety, sleep quality, total general health status, or fatigue. Conclusion Neurocognitive impairment can be confirmed in around 60% of individuals with self-reported deficits as part of post-COVID-19 syndrome following a mild acute COVID-19 disease course. Notably, screening tests cannot reliably detect this dysfunction. Standard psychiatric assessments showed no association with cognitive profiles. Longitudinal studies are needed to further evaluate the course of neurocognitive deficits and clarify pathophysiology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schild, Ann-Katrin UNSPECIFIED orcid.org/0000-0002-1920-0198 UNSPECIFIED Goereci, Yasemin UNSPECIFIED UNSPECIFIED UNSPECIFIED Scharfenberg, Daniel UNSPECIFIED orcid.org/0000-0003-2781-3143 UNSPECIFIED Klein, Kim UNSPECIFIED UNSPECIFIED UNSPECIFIED Luelling, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Meiberth, Dix UNSPECIFIED UNSPECIFIED UNSPECIFIED Schweitzer, Finja UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuermer, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeyen, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED Sahin, Derya UNSPECIFIED orcid.org/0000-0002-0573-0526 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Franke, Christiana UNSPECIFIED UNSPECIFIED UNSPECIFIED Onur, Oezguer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kessler, Josef UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnke, Clemens UNSPECIFIED orcid.org/0000-0002-3510-9255 UNSPECIFIED Maier, Franziska UNSPECIFIED orcid.org/0000-0002-9335-9594 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-688693
DOI:	10.1007/s00415-022-11444-w
Journal or Publication Title:	J. Neurol.
Volume:	270
Number:	3
Page Range:	S. 1215 - 1224
Date:	2023
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1459
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COVID-19; SEVERITY; SCALE; MOCA Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68869