Universität zu Köln

Weigert, Hannah, Stuckenschneider, Tim, Pickert, Lena, Rossi, Andrea, Meyer, Anna M., Nelles, Gereon, Schulz, Ralf-Joachim ORCID: 0000-0001-8844-8894, Stahl, Wilhelm, Schneider, Stefan and Polidori, M. Cristina (2022). Influence of a 12-Month Structured Exercise Program on the Micronutrient-Cognitive Fitness-Physical Association Profiles in Mild Cognitive Impairment. J. Alzheimers Dis. Rep., 6 (1). S. 711 - 723. AMSTERDAM: IOS PRESS. ISSN 2542-4823

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Abstract

Background: Preventive lifestyle strategies have shown promise to slow down or prevent age-related cognitive decline. However, evidence on the reciprocal longitudinal relationships between nutrition biomarkers and cognitive and physical performance is lacking. Studying nutritional, cognitive, and physical profiles over time may help to overcome this knowledge gap. Objective: To investigate the relationship of plasma levels of the robust nutritional- and antioxidant defense-related biomarkers carotenoids and tocopherols with both indicators of cognitive and physical performance in persons with mild cognitive impairment (MCI) participating in a structured exercise program. Methods: Data from 40 participants with MCI of the NeuroExercise study were analyzed. Participants had undergone a blood withdrawal for the analysis of plasma concentrations of six carotenoids, two tocopherols and retinol prior to and after one-year of structured exercise. All participants had undergone a broad spectrum of cognitive and physical performance tests. Results: Significant associations between lipophilic micronutrients and cognitive/physical measures were observed that were previously found to play a role in cognitive and physical frailty. In particular, lutein, zeaxanthin, and lycopene are confirmed as robust, reliable, and stable indicators of nutritional defense. Importantly, these micronutrients were associated with cognitive measures prior to the physical training program and to a more prominent extent with indicators of motoric function after the physical exercise program. Conclusion: Specific profiles of lipophilic micronutrients are associated to cognitive performance measures and, especially after a structured exercise program, to indicators of physical performance.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weigert, Hannah UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuckenschneider, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Pickert, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Rossi, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Anna M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nelles, Gereon UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Ralf-Joachim UNSPECIFIED orcid.org/0000-0001-8844-8894 UNSPECIFIED Stahl, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Polidori, M. Cristina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-689270
DOI:	10.3233/ADR-220039
Journal or Publication Title:	J. Alzheimers Dis. Rep.
Volume:	6
Number:	1
Page Range:	S. 711 - 723
Date:	2022
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	2542-4823
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALZHEIMERS-DISEASE; OXIDATIVE STRESS; OLDER-ADULTS; DEMENTIA; ANTIOXIDANT; LIFE; QUALITY; CAROTENOIDS; MECHANISMS; PREVENTION Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68927