Universität zu Köln

Mueller, Lukas, Maehringer-Kunz, Aline, Auer, Timo Alexander, Fehrenbach, Uli, Gebauer, Bernhard, Haubold, Johannes, Theysohn, Jens M., Kim, Moon-Sung, Kleesiek, Jens, Diallo, Thierno D., Eisenblaetter, Michel, Bettinger, Dominik, Steinle, Verena, Mayer, Philipp ORCID: 0000-0003-1957-1594, Zopfs, David, dos Santos, Daniel Pinto and Kloeckner, Roman (2023). Low bone mineral density is a prognostic factor for elderly patients with HCC undergoing TACE: results from a multicenter study. Eur. Radiol., 33 (2). S. 1031 - 1040. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

Objectives Low bone mineral density (BMD) was recently identified as a novel risk factor for patients with hepatocellular carcinoma (HCC). In this multicenter study, we aimed to validate the role of BMD as a prognostic factor for patients with HCC undergoing transarterial chemoembolization (TACE). Methods This retrospective multicenter trial included 908 treatment-naive patients with HCC who were undergoing TACE as a first-line treatment, at six tertiary care centers, between 2010 and 2020. BMD was assessed by measuring the mean Hounsfield units (HUs) in the midvertebral core of the 11(th) thoracic vertebra, on contrast-enhanced computer tomography performed before treatment. We assessed the influence of BMD on median overall survival (OS) and performed multivariate analysis including established estimates for survival. Results The median BMD was 145 HU (IQR, 115-175 HU). Patients with a high BMD (>= 114 HU) had a median OS of 22.2 months, while patients with a low BMD (< 114 HU) had a lower median OS of only 16.2 months (p < .001). Besides albumin, bilirubin, tumor number, and tumor diameter, BMD remained an independent prognostic factor in multivariate analysis. Conclusions BMD is an independent predictive factor for survival in elderly patients with HCC undergoing TACE. The integration of BMD into novel scoring systems could potentially improve survival prediction and clinical decision-making.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Maehringer-Kunz, Aline UNSPECIFIED UNSPECIFIED UNSPECIFIED Auer, Timo Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Fehrenbach, Uli UNSPECIFIED UNSPECIFIED UNSPECIFIED Gebauer, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Haubold, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Theysohn, Jens M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Moon-Sung UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleesiek, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Diallo, Thierno D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eisenblaetter, Michel UNSPECIFIED UNSPECIFIED UNSPECIFIED Bettinger, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinle, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Mayer, Philipp UNSPECIFIED orcid.org/0000-0003-1957-1594 UNSPECIFIED Zopfs, David UNSPECIFIED UNSPECIFIED UNSPECIFIED dos Santos, Daniel Pinto UNSPECIFIED UNSPECIFIED UNSPECIFIED Kloeckner, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-689774
DOI:	10.1007/s00330-022-09069-8
Journal or Publication Title:	Eur. Radiol.
Volume:	33
Number:	2
Page Range:	S. 1031 - 1040
Date:	2023
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BEAD TRANSARTERIAL CHEMOEMBOLIZATION; HEPATOCELLULAR-CARCINOMA; OSTEOPOROSIS; DIAGNOSIS Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68977