Universität zu Köln

Herssens, Nolan, Cowburn, James ORCID: 0000-0001-8122-3334, Albracht, Kirsten ORCID: 0000-0002-4271-2511, Braunstein, Bjoern ORCID: 0000-0002-5173-8916, Cazzola, Dario ORCID: 0000-0001-7877-6755, Colyer, Steffi, Minetti, Alberto E., Pavei, Gaspare ORCID: 0000-0002-0109-4964, Rittweger, Jorn, Weber, Tobias and Green, David A. (2022). Movement in low gravity environments (MoLo) programme-The MoLo-LOOP study protocol. PLoS One, 17 (11). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Background Exposure to prolonged periods in microgravity is associated with deconditioning of the musculoskeletal system due to chronic changes in mechanical stimulation. Given astronauts will operate on the Lunar surface for extended periods of time, it is critical to quantify both external (e.g., ground reaction forces) and internal (e.g., joint reaction forces) loads of relevant movements performed during Lunar missions. Such knowledge is key to predict musculoskeletal deconditioning and determine appropriate exercise countermeasures associated with extended exposure to hypogravity. Objectives The aim of this paper is to define an experimental protocol and methodology suitable to estimate in high-fidelity hypogravity conditions the lower limb internal joint reaction forces. State-of-the-art movement kinetics, kinematics, muscle activation and muscle-tendon unit behaviour during locomotor and plyometric movements will be collected and used as inputs (Objective 1), with musculoskeletal modelling and an optimisation framework used to estimate lower limb internal joint loading (Objective 2). Methods Twenty-six healthy participants will be recruited for this cross-sectional study. Participants will walk, skip and run, at speeds ranging between 0.56-3.6 m/s, and perform plyometric movement trials at each gravity level (1, 0.7, 0.5, 0.38, 0.27 and 0.16g) in a randomized order. Through the collection of state-of-the-art kinetics, kinematics, muscle activation and muscle-tendon behaviour, a musculoskeletal modelling framework will be used to estimate lower limb joint reaction forces via tracking simulations. Conclusion The results of this study will provide first estimations of internal musculoskeletal loads associated with human movement performed in a range of hypogravity levels. Thus, our unique data will be a key step towards modelling the musculoskeletal deconditioning associated with long term habitation on the Lunar surface, and thereby aiding the design of Lunar exercise countermeasures and mitigation strategies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herssens, Nolan UNSPECIFIED UNSPECIFIED UNSPECIFIED Cowburn, James UNSPECIFIED orcid.org/0000-0001-8122-3334 UNSPECIFIED Albracht, Kirsten UNSPECIFIED orcid.org/0000-0002-4271-2511 UNSPECIFIED Braunstein, Bjoern UNSPECIFIED orcid.org/0000-0002-5173-8916 UNSPECIFIED Cazzola, Dario UNSPECIFIED orcid.org/0000-0001-7877-6755 UNSPECIFIED Colyer, Steffi UNSPECIFIED UNSPECIFIED UNSPECIFIED Minetti, Alberto E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pavei, Gaspare UNSPECIFIED orcid.org/0000-0002-0109-4964 UNSPECIFIED Rittweger, Jorn UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Green, David A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-689951
DOI:	10.1371/journal.pone.0278051
Journal or Publication Title:	PLoS One
Volume:	17
Number:	11
Date:	2022
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROUND REACTION FORCES; MUSCULOSKELETAL MODEL; MUSCLE; LOCOMOTION; BONE; SIMULATION; GAIT; REHABILITATION; BIOMECHANICS; MECHANOSTAT Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68995