Universität zu Köln

Wiegering, Verena, Riedmeier, Maria, Thompson, Lester D. R., Virgone, Calogero ORCID: 0000-0002-3651-9416, Redlich, Antje ORCID: 0000-0002-1732-1869, Kuhlen, Michaela, Gultekin, Melis, Yalcin, Bilgehan, Decarolis, Boris ORCID: 0000-0002-1607-0543, Haertel, Christoph, Schlegel, Paul-Gerhardt, Fassnacht, Martin and Timmermann, Beate (2022). Radiotherapy for pediatric adrenocortical carcinoma - Review of the literature. Clin. Transl. Radiat. Oncol., 35. S. 56 - 64. CLARE: ELSEVIER IRELAND LTD. ISSN 2405-6308

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Abstract

Background and purpose: Pediatric adrenocortical carcinoma (pACC) is a rare disease with poor prognosis. Pub-lications on radiotherapy (RT) ar e scarce. This review summarizes the current data on RT for pACC and possibly provides first evidence to justi f y its use in this setting. Materials and methods: We searched the PubMed and Embase database for manuscripts regarding RT for pACC. Results: We included 17 manuscripts reporting on 76 patients treated with RT, after screenin g 2961 references and 269 f u l l articles. In addition, we added data of 4 unreported pACC patients treated by co-authors. A l l reports based on retrospective data. Median age at first diagnosis was 11.1 years (70% female); 78% of patients pre-sented with hormonal activity. RT was mostly performed for curative intent (78%). 88% of RT were administered during primary therapy. The site of RT was predominantly the local tumor bed (76%). Doses of RT ranged from 15 to 62 Gy (median 50 Gy). Information on target volumes or fractionation were lacking. Median follow-up was 6,9 years and 64% of the patients died of disease, with 33% alive without disease. In 16 of 48 patients with available follow-up data after adjuvant RT (33%) no recurrence was reported and in 3 of 9 patients palliative RT seemed to induce some benefit for the patient. Conclusions: Our first systematic review on RT for pACC provides too few data for any general recommendation, but adjuvant RT in patients with high risk might be considered. International collaborative studies are urgently needed to establish better evidence on the role of RT in this rare malignancy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wiegering, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedmeier, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Thompson, Lester D. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Virgone, Calogero UNSPECIFIED orcid.org/0000-0002-3651-9416 UNSPECIFIED Redlich, Antje UNSPECIFIED orcid.org/0000-0002-1732-1869 UNSPECIFIED Kuhlen, Michaela UNSPECIFIED UNSPECIFIED UNSPECIFIED Gultekin, Melis UNSPECIFIED UNSPECIFIED UNSPECIFIED Yalcin, Bilgehan UNSPECIFIED UNSPECIFIED UNSPECIFIED Decarolis, Boris UNSPECIFIED orcid.org/0000-0002-1607-0543 UNSPECIFIED Haertel, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlegel, Paul-Gerhardt UNSPECIFIED UNSPECIFIED UNSPECIFIED Fassnacht, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-690002
DOI:	10.1016/j.ctro.2022.05.003
Journal or Publication Title:	Clin. Transl. Radiat. Oncol.
Volume:	35
Page Range:	S. 56 - 64
Date:	2022
Publisher:	ELSEVIER IRELAND LTD
Place of Publication:	CLARE
ISSN:	2405-6308
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ADRENAL-CORTICAL TUMORS; LI-FRAUMENI SYNDROME; PROGNOSTIC-FACTORS; HOSPITAL VOLUME; CHILDREN; MANAGEMENT; CHILDHOOD; NEOPLASMS; MUTATION; IMPACT Multiple languages Oncology; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69000