Universität zu Köln

Feenstra, Helena M. A., Hahn, Leo C., van Rijssen, Thomas J., Tsonaka, Roula, Breukink, Myrte B., Keunen, Jan E. E., Peters, Petrus J. H., Dijkman, Greet, Souied, Eric H., MacLaren, Robert E., Querques, Giuseppe ORCID: 0000-0002-3292-9581, Downes, Susan M., Fauser, Sascha, Hoyng, Carel B., van Dijk, Elon H. C. and Boon, Camiel J. F. (2022). EFFICACY OF HALF-DOSE PHOTODYNAMIC THERAPY VERSUS HIGH-DENSITY SUBTHRESHOLD MICROPULSE LASER FOR TREATING PIGMENT EPITHELIAL DETACHMENTS IN CHRONIC CENTRAL SEROUS CHORIORETINOPATHY. Retin.-J. Retin. Vitr. Dis., 42 (4). S. 721 - 730. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1539-2864

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Abstract

Purpose: Comparing the effect of half-dose photodynamic therapy and high-density subthreshold micropulse laser treatment on retinal pigment epithelial detachments (PEDs) in chronic central serous chorioretinopathy. Methods: This study included data from the PLACE trial, a prospective randomized controlled trial comparing half-dose photodynamic therapy and high-density subthreshold micropulse laser treatment in chronic central serous chorioretinopathy. Main outcome measurements were changes in both the foveal PED and the highest PED within the macula at baseline compared with first and final evaluation visit. Results: At baseline, a macular PED was detected in 76.9% of patients (123/160), and a PED within 1,500 mu m from the foveal center in 37.5% of patients (60/160). In the half-dose photodynamic therapy arm (61 patients), there was a significantly larger decrease in the highest macular PED compared with the high-density subthreshold micropulse laser treatment arm (62 patients) at both first and final evaluation visits (P < 0.001 and P = 0.012, respectively). The decrease of highest foveal PED was significant at first visit (P = 0.025). Conclusion: Half-dose photodynamic therapy is superior to high-density subthreshold micropulse laser treatment with regard to a statistically significant reduction in the height of macular PEDs in active chronic central serous chorioretinopathy. These findings may also have implications for other diseases within the pachychoroid disease spectrum that can present with PEDs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Feenstra, Helena M. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, Leo C. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Rijssen, Thomas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tsonaka, Roula UNSPECIFIED UNSPECIFIED UNSPECIFIED Breukink, Myrte B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Keunen, Jan E. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Petrus J. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dijkman, Greet UNSPECIFIED UNSPECIFIED UNSPECIFIED Souied, Eric H. UNSPECIFIED UNSPECIFIED UNSPECIFIED MacLaren, Robert E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Querques, Giuseppe UNSPECIFIED orcid.org/0000-0002-3292-9581 UNSPECIFIED Downes, Susan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Dijk, Elon H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boon, Camiel J. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-691724
DOI:	10.1097/IAE.0000000000003363
Journal or Publication Title:	Retin.-J. Retin. Vitr. Dis.
Volume:	42
Number:	4
Page Range:	S. 721 - 730
Date:	2022
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1539-2864
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THICKNESS; DISEASE Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69172