Universität zu Köln

Beckerman, Rachel, Gori, Andrea, Jeyakumar, Sushanth, Malin, Jakob J. ORCID: 0000-0002-2989-0436, Paredes, Roger, Povoa, Pedro, Smith, Nathaniel J. and Teixeira-Pinto, Armando ORCID: 0000-0002-9389-2516 (2022). Remdesivir for the treatment of patients hospitalized with COVID-19 receiving supplemental oxygen: a targeted literature review and meta-analysis. Sci Rep, 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

This network meta-analysis (NMA) assessed the efficacy of remdesivir in hospitalized patients with COVID-19 requiring supplemental oxygen. Randomized controlled trials of hospitalized patients with COVID-19, where patients were receiving supplemental oxygen at baseline and at least one arm received treatment with remdesivir, were identified. Outcomes included mortality, recovery, and no longer requiring supplemental oxygen. NMAs were performed for low-flow oxygen (LFO2); high-flow oxygen (HFO2), including NIV (non-invasive ventilation); or oxygen at any flow (AnyO(2)) at early (day 14/15) and late (day 28/29) time points. Six studies were included (N = 5245 patients) in the NMA. Remdesivir lowered early and late mortality among AnyO(2) patients (risk ratio (RR) 0.52, 95% credible interval (CrI) 0.34-0.79; RR 0.81, 95%CrI 0.69-0.95) and LFO2 patients (RR 0.21, 95%CrI 0.09-0.46; RR 0.24, 95%CrI 0.11-0.48); no improvement was observed among HFO2 patients. Improved early and late recovery was observed among LFO2 patients (RR 1.22, 95%CrI 1.09-1.38; RR 1.17, 95%CrI 1.09-1.28). Remdesivir also lowered the requirement for oxygen support among all patient subgroups. Among hospitalized patients with COVID-19 requiring supplemental oxygen at baseline, use of remdesivir compared to best supportive care is likely to improve the risk of mortality, recovery and need for oxygen support in AnyO(2) and LFO2 patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Beckerman, Rachel UNSPECIFIED UNSPECIFIED UNSPECIFIED Gori, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Jeyakumar, Sushanth UNSPECIFIED UNSPECIFIED UNSPECIFIED Malin, Jakob J. UNSPECIFIED orcid.org/0000-0002-2989-0436 UNSPECIFIED Paredes, Roger UNSPECIFIED UNSPECIFIED UNSPECIFIED Povoa, Pedro UNSPECIFIED UNSPECIFIED UNSPECIFIED Smith, Nathaniel J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Teixeira-Pinto, Armando UNSPECIFIED orcid.org/0000-0002-9389-2516 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-691802
DOI:	10.1038/s41598-022-13680-6
Journal or Publication Title:	Sci Rep
Volume:	12
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69180