Weber, Cora, Fangauf, Stella V. ORCID: 0000-0001-6245-0152, Michal, Matthias, Ronel, Joram ORCID: 0000-0002-2272-8831, Herrmann-Lingen, Christoph, Ladwig, Karl-Heinz ORCID: 0000-0003-0710-1720, Beutel, Manfred, Albus, Christian, Sollner, Wolfgang, Perschel, Frank Holger ORCID: 0000-0001-5223-6099, de Zwaan, Martina ORCID: 0000-0002-7918-6957, Fritzsche, Kurt and Deter, Hans-Christian ORCID: 0000-0001-8575-4570 (2022). Cortisol Awakening Reaction and Anxiety in Depressed Coronary Artery Disease Patients. J. Clin. Med., 11 (2). BASEL: MDPI. ISSN 2077-0383

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Abstract

Disturbances of HPA axis functioning as represented by cortisol awakening reaction (CAR) belong to the mediating pathways linking psychosocial distress and cardiovascular risk. Both depression and anxiety have been confirmed as independent risk factors for coronary artery disease (CAD). However, data on anxiety and cortisol output in CAD patients are scarce. Based on previous data, we hypothesized that anxiety would be associated with higher cortisol output and a more pronounced morning increase in moderately depressed CAD patients. 77 patients (60 y, 79% male) underwent saliva sampling (+0, +30, +45, +60 min after awakening, midday and late-night sample). Anxiety was measured using the Hospital Anxiety and Depression Scale (HADS) and patients were grouped into anxious versus non anxious subjects based upon the recommended score (>= 11). A repeated measures ANOVA yielded a significant time and quadratic time effect referring to the typical CAR. Anxious patients showed a significantly steeper 30 min increase, higher AUCi, lower waking and late-night cortisol levels. The steeper cortisol increase in the anxious group is in line with previous data and may be interpreted as a biological substrate of affect regulation. The lower basal and late-night levels coupled with greater AUCi mirror a more dynamic reactivity pattern compared to depressed subjects without anxiety.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Weber, CoraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fangauf, Stella V.UNSPECIFIEDorcid.org/0000-0001-6245-0152UNSPECIFIED
Michal, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ronel, JoramUNSPECIFIEDorcid.org/0000-0002-2272-8831UNSPECIFIED
Herrmann-Lingen, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ladwig, Karl-HeinzUNSPECIFIEDorcid.org/0000-0003-0710-1720UNSPECIFIED
Beutel, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albus, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sollner, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perschel, Frank HolgerUNSPECIFIEDorcid.org/0000-0001-5223-6099UNSPECIFIED
de Zwaan, MartinaUNSPECIFIEDorcid.org/0000-0002-7918-6957UNSPECIFIED
Fritzsche, KurtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deter, Hans-ChristianUNSPECIFIEDorcid.org/0000-0001-8575-4570UNSPECIFIED
URN: urn:nbn:de:hbz:38-692026
DOI: 10.3390/jcm11020374
Journal or Publication Title: J. Clin. Med.
Volume: 11
Number: 2
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2077-0383
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STEPWISE PSYCHOTHERAPY INTERVENTION; HEART-DISEASE; SALIVARY CORTISOL; PROGNOSTIC ASSOCIATION; MYOCARDIAL-INFARCTION; RANDOMIZED-TRIAL; REDUCING RISK; SPIRR-CAD; STRESS; EVENTSMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69202

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