Universität zu Köln

Wang, Xiaoqi, Bi, Qiuhui, Lu, Jie, Chan, Piu, Hu, Xiaochen ORCID: 0000-0003-4126-673X, Su, Li, Jessen, Frank, Lin, Hua, Han, Chunlei, Shu, Ni, Liu, Hesheng and Han, Ying (2022). Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Study from the SILCODE. J. Alzheimers Dis., 85 (4). S. 1573 - 1583. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Background: Subjective cognitive decline (SCD), an at-risk condition of Alzheimer's disease (AD), can involve various cognitive domains, such as memory, language, planning, and attention. Objective: We aim to explore the difference in amyloid load between the single memory domain SCD (sd-SCD) and the multidomain SCD (md-SCD) and assess the relationship of amyloid pathology with quantitative SCD scores and objective cognition. Methods: A total of 63 SCD participants from the SILCODE study underwent the clinical evaluation, neuropsychological assessment, and F-18-florbetapir PET scan. Global amyloid standard uptake value ratio (SUVr) was calculated. Additionally, regional amyloid SUVr was quantified in 12 brain regions of interests. A nonparametric rank ANCOVA was used to compare the global and regional amyloid SUVr between the md-SCD (n = 34) and sd-SCD (n = 29) groups. A multiple linear regression analysis was conducted to test the relationship of amyloid SUVr with quantitative SCD scores and objective cognition. Results: Compared with individuals with sd-SCD, individuals with md-SCD had increased global amyloid SUVr (F = 5.033, p = 0.029) and regional amyloid SUVr in the left middle temporal gyrus (F = 12.309, p = 0.001; Bonferroni corrected), after controlling for the effects of age, sex, and education. When pooling all SCD participants together, the increased global amyloid SUVr was related with higher SCD-plus sum scores and lower Auditory Verbal Learning Test-delayed recall scores. Conclusion: According to our findings, individuals with md-SCD showed higher amyloid accumulation than individuals with sd-SCD, suggesting that md-SCD may experience a more advanced stage of SCD. Additionally, increased global amyloid load was predictive of a poorer episodic memory function in SCD individuals.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wang, Xiaoqi UNSPECIFIED UNSPECIFIED UNSPECIFIED Bi, Qiuhui UNSPECIFIED UNSPECIFIED UNSPECIFIED Lu, Jie UNSPECIFIED UNSPECIFIED UNSPECIFIED Chan, Piu UNSPECIFIED UNSPECIFIED UNSPECIFIED Hu, Xiaochen UNSPECIFIED orcid.org/0000-0003-4126-673X UNSPECIFIED Su, Li UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Hua UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Chunlei UNSPECIFIED UNSPECIFIED UNSPECIFIED Shu, Ni UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Hesheng UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Ying UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-692489
DOI:	10.3233/JAD-215373
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	85
Number:	4
Page Range:	S. 1573 - 1583
Date:	2022
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALZHEIMERS-DISEASE; CLINICAL PROGRESSION; OLDER-ADULTS; BETA; COMPLAINTS; BRAIN; DEPOSITION; FRAMEWORK; BURDEN; PET Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69248