Mueller, Hendrik, Betz, Linda T. ORCID: 0000-0003-1741-4069, Kambeitz, Joseph ORCID: 0000-0002-8988-3959, Falkai, Peter, Gaebel, Wolfgang, Heinz, Andreas ORCID: 0000-0001-5405-9065, Hellmich, Martin, Juckel, Georg, Lambert, Martin, Meyer-Lindenberg, Andreas, Schneider, Frank ORCID: 0000-0003-1557-7956, Wagner, Michael, Zink, Mathias, Klosterkotter, Joachim and Bechdolf, Andreas (2022). Bridging the phenomenological gap between predictive basic-symptoms and attenuated positive symptoms: a cross-sectional network analysis. Schizophr., 8 (1). BERLIN: NATURE PORTFOLIO. ISSN 2754-6993

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Abstract

Attenuated positive symptoms (APS), transient psychotic-like symptoms (brief, limited intermittent psychotic symptoms, BLIPS), and predictive cognitive-perceptive basic-symptoms (BS) criteria can help identify a help-seeking population of young people at clinical high-risk of a first episode psychosis (CHRp). Phenomenological, there are substantial differences between BS and APS or BLIPS. BS do not feature psychotic content as delusion or hallucinations, and reality testing is preserved. One fundamental problem in the psychopathology of CHRp is to understand how the non-psychotic BS are related to APS. To explore the interrelationship of APS and predictive BS, we fitted a network analysis to a dataset of 231 patients at CHRp, aged 24.4 years (SD = 5.3) with 65% male. Particular emphasis was placed on points of interaction (bridge symptoms) between the two criteria sets. The BS 'unstable ideas of reference' and inability to discriminate between imagination and reality interacted with attenuated delusional ideation. Perceptual BS were linked to perceptual APS. Albeit central for the network, predictive cognitive basic BS were relatively isolated from APS. Our analysis provides empirical support for existing theoretical accounts that interaction between the distinct phenomenological domains of BS and APS is characterized by impairments in source monitoring and perspective-taking. Identifying bridge symptoms between the symptom domains holds the potential to empirically advance the etiological understanding of psychosis and pave the way for tailored clinical interventions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mueller, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Betz, Linda T.UNSPECIFIEDorcid.org/0000-0003-1741-4069UNSPECIFIED
Kambeitz, JosephUNSPECIFIEDorcid.org/0000-0002-8988-3959UNSPECIFIED
Falkai, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaebel, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinz, AndreasUNSPECIFIEDorcid.org/0000-0001-5405-9065UNSPECIFIED
Hellmich, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juckel, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lambert, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer-Lindenberg, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, FrankUNSPECIFIEDorcid.org/0000-0003-1557-7956UNSPECIFIED
Wagner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zink, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkotter, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bechdolf, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-692735
DOI: 10.1038/s41537-022-00274-4
Journal or Publication Title: Schizophr.
Volume: 8
Number: 1
Date: 2022
Publisher: NATURE PORTFOLIO
Place of Publication: BERLIN
ISSN: 2754-6993
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PRODROMAL SYMPTOMS; INITIAL PRODROME; SCHIZOPHRENIA; PSYCHOSIS; SCALE; RISK; PREVENTION; CENTRALITYMultiple languages
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69273

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