Manka, Paul ORCID: 0000-0001-8589-7280, Sydor, Svenja, Schaenzer-Ocklenburg, Julia M., Brandenburg, Malte, Best, Jan, Vilchez-Vargas, Ramiro ORCID: 0000-0001-6535-8212, Link, Alexander ORCID: 0000-0002-9514-4562, Heider, Dominik, Brodesser, Susanne, Figge, Anja, Jaehnert, Andreas, Coombes, Jason D., Javier Cubero, Francisco, Kahraman, Alisan ORCID: 0000-0002-2823-6774, Kim, Moon-Sung, Kaelsch, Julia, Kinner, Sonja, Faber, Klaas Nico, Moshage, Han ORCID: 0000-0002-4764-0246, Gerken, Guido, Syn, Wing-Kin, Canbay, Ali ORCID: 0000-0001-6069-7899 and Bechmann, Lars P. (2022). A Potential Role for Bile Acid Signaling in Celiac Disease-Associated Fatty Liver. Metabolites, 12 (2). BASEL: MDPI. ISSN 2218-1989

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Abstract

Celiac disease (CeD) is a chronic autoimmune disorder characterized by an intolerance to storage proteins of many grains. CeD is frequently associated with liver damage and steatosis. Bile acid (BA) signaling has been identified as an important mediator in gut-liver interaction and the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Here, we aimed to analyze BA signaling and liver injury in CeD patients. Therefore, we analyzed data of 20 CeD patients on a gluten-free diet compared to 20 healthy controls (HC). We furthermore analyzed transaminase levels, markers of cell death, BA, and fatty acid metabolism. Hepatic steatosis was determined via transient elastography, by MRI and non-invasive scores. In CeD, we observed an increase of the apoptosis marker M30 and more hepatic steatosis as compared to HC. Fibroblast growth factor 19 (FGF19) was repressed in CeD, while low levels were associated with steatosis, especially in patients with high levels of antitissue transglutaminase antibodies (anti-tTG). When comparing anti-tTG-positive CeD patients to individuals without detectable anti-tTG levels, hepatic steatosis was accentuated. CeD patients with significant sonographic steatosis (defined by CAP >= 283 db/m) were exclusively anti-tTG-positive. In summary, our results suggest that even in CeD patients in clinical remission under gluten-free diet, alterations in gut-liver axis, especially BA signaling, might contribute to steatotic liver injury and should be further addressed in future studies and clinical practice.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Manka, PaulUNSPECIFIEDorcid.org/0000-0001-8589-7280UNSPECIFIED
Sydor, SvenjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaenzer-Ocklenburg, Julia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandenburg, MalteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Best, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vilchez-Vargas, RamiroUNSPECIFIEDorcid.org/0000-0001-6535-8212UNSPECIFIED
Link, AlexanderUNSPECIFIEDorcid.org/0000-0002-9514-4562UNSPECIFIED
Heider, DominikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brodesser, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Figge, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaehnert, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coombes, Jason D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Javier Cubero, FranciscoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kahraman, AlisanUNSPECIFIEDorcid.org/0000-0002-2823-6774UNSPECIFIED
Kim, Moon-SungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaelsch, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kinner, SonjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faber, Klaas NicoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moshage, HanUNSPECIFIEDorcid.org/0000-0002-4764-0246UNSPECIFIED
Gerken, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Syn, Wing-KinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canbay, AliUNSPECIFIEDorcid.org/0000-0001-6069-7899UNSPECIFIED
Bechmann, Lars P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-694289
DOI: 10.3390/metabo12020130
Journal or Publication Title: Metabolites
Volume: 12
Number: 2
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2218-1989
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NONALCOHOLIC STEATOHEPATITIS; INVOLVEMENT; PREVALENCEMultiple languages
Biochemistry & Molecular BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69428

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