Universität zu Köln

Sari Motlagh, Reza, Yanagisawa, Takafumi ORCID: 0000-0002-7410-0712, Kawada, Tatsushi ORCID: 0000-0002-8369-9712, Laukhtina, Ekaterina ORCID: 0000-0002-8953-0272, Rajwa, Pawel, Aydh, Abdulmajeed, Koenig, Frederik, Pallauf, Maximilan, Huebner, Nicolai A., Baltzer, Pascal A., Karakiewicz, Pierre I., Heidenreich, Axel and Shariat, Shahrokh F. (2022). Accuracy of SelectMDx compared to mpMRI in the diagnosis of prostate cancer: a systematic review and diagnostic meta-analysis. Prostate Cancer Prostatic Dis., 25 (2). S. 187 - 199. LONDON: SPRINGERNATURE. ISSN 1476-5608

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Abstract

Background The SelectMDx test is a promising biomarker that is developed based on detecting urinary messenger RNA in combination with clinical prostate cancer (PCa) risk factors. We aimed to compare SelectMDx and mpMRI as a diagnostic test in detecting PCa and high grade(HG)-PCa in men suspected to have PCa. Methods According to PRISMA, a systematic search was performed using major web databases for studies published before September 30, 2021. Studies that compared sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of SelectMDx and/or mpMRI were included. The bivariate random model that plotted sensitivity, specificity, PPV, NPV, and likelihood ratio (LR) for PCa and HG-PCa detection was applied to compare SelectMDx, mpMRI, and combination strategies (both positive and one or both positive). Results Seven studies comprising 1328 patients who had undergone SelectMDx and mpMRI to detect PCa were included. Regarding PCa detection, SelectMDx had a pooled sensitivity of 81%, specificity of 69.8%, PPV of 64.7%, NPV of 85%, and LRs of +2.68 to -0.27, while mpMRI had a pooled sensitivity of 80.8%, specificity of 73.4%, PPV of 72.4%, NPV of 83.5%, and LRs of +3.03 to -0.26. The one or both positive strategy had the highest sensitivity (96.3%), NPV (95.7%), and the lowest -LR (0.06). While the both positive strategy had the highest specificity (80.9%), the PPV (76.5%) and +LR (3.68). In the scenario of PI-RADS 3 lesions not being biopsied in case of a negative SelectMDx (n = 44), unnecessary biopsies would be reduced by 42% (44/105) while the risk of missing HG-PCa would be 9% (4/44). Conclusion The performance of SelectMDx is comparable to that of mpMRI with regards to PCa and HG-PCa detection. In addition, this biomarker could help refine the clinical decision-making regarding the necessity of a biopsy in patients suspected to has been PCa.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sari Motlagh, Reza UNSPECIFIED UNSPECIFIED UNSPECIFIED Yanagisawa, Takafumi UNSPECIFIED orcid.org/0000-0002-7410-0712 UNSPECIFIED Kawada, Tatsushi UNSPECIFIED orcid.org/0000-0002-8369-9712 UNSPECIFIED Laukhtina, Ekaterina UNSPECIFIED orcid.org/0000-0002-8953-0272 UNSPECIFIED Rajwa, Pawel UNSPECIFIED UNSPECIFIED UNSPECIFIED Aydh, Abdulmajeed UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Frederik UNSPECIFIED UNSPECIFIED UNSPECIFIED Pallauf, Maximilan UNSPECIFIED UNSPECIFIED UNSPECIFIED Huebner, Nicolai A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baltzer, Pascal A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karakiewicz, Pierre I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heidenreich, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Shariat, Shahrokh F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-695618
DOI:	10.1038/s41391-022-00538-1
Journal or Publication Title:	Prostate Cancer Prostatic Dis.
Volume:	25
Number:	2
Page Range:	S. 187 - 199
Date:	2022
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1476-5608
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MULTIPARAMETRIC MRI; HIGH-GRADE; BIOPSY; MEN; PREVALENCE Multiple languages Oncology; Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69561