Blank, Norbert, Schmalzing, Marc, Moinzadeh, Pia, Oberste, Max, Siegert, Elise ORCID: 0000-0002-9594-0446, Mueller-Ladner, Ulf, Riemekasten, Gabriela, Guenther, Claudia, Koetter, Ina, Zeidler, Gabriele, Pfeiffer, Christiane, Juche, Aaron, Jandova, Ilona, Ehrchen, Jan, Susok, Laura, Schmeiser, Tim, Sunderkoetter, Cord, Distler, Jorg H. W., Worm, Margitta, Kreuter, Alexander, Keysser, Gernot, Lorenz, Hanns-Martin, Krieg, Thomas, Hunzelmann, Nicolas and Henes, Jorg (2022). Autologous hematopoietic stem cell transplantation improves long-term survival-data from a national registry. Arthritis Res. Ther., 24 (1). LONDON: BMC. ISSN 1478-6362

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Abstract

Background Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell therapy (HSCT) can be a rescue therapy for patients with rapidly progressive SSc. Objectives To assess the safety and efficacy of HSCT for patients with SSc and to compare these with non-HSCT patients in a control cohort with adjusted risk factors. Methods A retrospective analysis of data from the multicentric German network for systemic scleroderma (DNSS) with 5000 patients with SSc. Control groups consisted of all patients with diffuse cutaneous (dc)-SSc (group A) and an adjusted high-risk cohort of male patients with Scl70-positive dc-SSc (group B). Results Eighty SSc patients received an HSCT 4.1 +/- 4.8 years after SSc diagnosis. Among them, 86.3% had dc-SSc, 43.5% were males, and 71.3% were positive for Scl70 antibodies. The control group A (n=1513) showed a significant underrepresentation of these risk factors for mortality. When the survival of the control group B (n=240) was compared with the HSCT group, a lower mortality of the latter was observed instead. Within 5 years after HSCT, we observed an improvement of the mRSS from 17.6 +/- 11.5 to 11.0 +/- 8.5 (p=0.001) and a stabilization of the DLCO. We did not see differences in transplant-related mortality between patients who received HSCT within 3 years after SSc diagnosis or later. Conclusion Our analysis of real-life data show that the distribution of risk factors for mortality is critical when HSCT cohorts are compared with non-HSCT control groups.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Blank, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmalzing, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moinzadeh, PiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oberste, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siegert, EliseUNSPECIFIEDorcid.org/0000-0002-9594-0446UNSPECIFIED
Mueller-Ladner, UlfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riemekasten, GabrielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guenther, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koetter, InaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeidler, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeiffer, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juche, AaronUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jandova, IlonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ehrchen, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Susok, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmeiser, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sunderkoetter, CordUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Distler, Jorg H. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Worm, MargittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreuter, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keysser, GernotUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lorenz, Hanns-MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krieg, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunzelmann, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henes, JorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-696428
DOI: 10.1186/s13075-022-02948-x
Journal or Publication Title: Arthritis Res. Ther.
Volume: 24
Number: 1
Date: 2022
Publisher: BMC
Place of Publication: LONDON
ISSN: 1478-6362
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DIFFUSE SYSTEMIC-SCLEROSIS; PULSE CYCLOPHOSPHAMIDE; DOUBLE-BLIND; SCLERODERMA; CLASSIFICATION; PATTERNS; CRITERIA; SUBSETSMultiple languages
RheumatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69642

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