Gui, Xianyong, Bazarova, Alina, Del Amor, Rocio, Vieth, Michael, de Hertogh, Gert, Villanacci, Vincenzo, Zardo, Davide, Parigi, Tommaso Lorenzo ORCID: 0000-0002-3398-0231, Royset, Elin Synnove, Shivaji, Uday N., Monica, Melissa Anna Teresa, Mandelli, Giulio, Bhandari, Pradeep, Danese, Silvio, Ferraz, Jose G., Hayee, Bu'Hussain ORCID: 0000-0003-1670-8815, Lazarev, Mark, Parra-Blanco, Adolfo, Pastorelli, Luca ORCID: 0000-0002-2810-9951, Panaccione, Remo, Rath, Timo ORCID: 0000-0002-7728-9338, Tontini, Gian Eugenio, Kiesslich, Ralf, Bisschops, Raf ORCID: 0000-0002-9994-8226, Grisan, Enrico ORCID: 0000-0002-7365-5652, Naranjo, Valery ORCID: 0000-0002-0181-3412, Ghosh, Subrata and Iacucci, Marietta (2022). PICaSSO Histologic Remission Index (PHRI) in ulcerative colitis: development of a novel simplified histological score for monitoring mucosal healing and predicting clinical outcomes and its applicability in an artificial intelligence system. Gut, 71 (5). S. 889 - 899. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-3288

Full text not available from this repository.

Abstract

Histological remission is evolving as an important treatment target in UC. We aimed to develop a simple histological index, aligned to endoscopy, correlated with clinical outcomes, and suited to apply to an artificial intelligence (AI) system to evaluate inflammatory activity. Methods Using a set of 614 biopsies from 307 patients with UC enrolled into a prospective multicentre study, we developed the Paddington International virtual ChromoendoScopy ScOre (PICaSSO) Histologic Remission Index (PHRI). Agreement with multiple other histological indices and validation for inter-reader reproducibility were assessed. Finally, to implement PHRI into a computer-aided diagnosis system, we trained and tested a novel deep learning strategy based on a CNN architecture to detect neutrophils, calculate PHRI and identify active from quiescent UC using a subset of 138 biopsies. Results PHRI is strongly correlated with endoscopic scores (Mayo Endoscopic Score and UC Endoscopic Index of Severity and PICaSSO) and with clinical outcomes (hospitalisation, colectomy and initiation or changes in medical therapy due to UC flare-up). A PHRI score of 1 could accurately stratify patients' risk of adverse outcomes (hospitalisation, colectomy and treatment optimisation due to flare-up) within 12 months. Our inter-reader agreement was high (intraclass correlation 0.84). Our preliminary AI algorithm differentiated active from quiescent UC with 78% sensitivity, 91.7% specificity and 86% accuracy. Conclusions PHRI is a simple histological index in UC, and it exhibits the highest correlation with endoscopic activity and clinical outcomes. A PHRI-based AI system was accurate in predicting histological remission.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gui, XianyongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bazarova, AlinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Del Amor, RocioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vieth, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Hertogh, GertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villanacci, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zardo, DavideUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parigi, Tommaso LorenzoUNSPECIFIEDorcid.org/0000-0002-3398-0231UNSPECIFIED
Royset, Elin SynnoveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shivaji, Uday N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monica, Melissa Anna TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mandelli, GiulioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bhandari, PradeepUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Danese, SilvioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferraz, Jose G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hayee, Bu'HussainUNSPECIFIEDorcid.org/0000-0003-1670-8815UNSPECIFIED
Lazarev, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parra-Blanco, AdolfoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pastorelli, LucaUNSPECIFIEDorcid.org/0000-0002-2810-9951UNSPECIFIED
Panaccione, RemoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rath, TimoUNSPECIFIEDorcid.org/0000-0002-7728-9338UNSPECIFIED
Tontini, Gian EugenioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiesslich, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bisschops, RafUNSPECIFIEDorcid.org/0000-0002-9994-8226UNSPECIFIED
Grisan, EnricoUNSPECIFIEDorcid.org/0000-0002-7365-5652UNSPECIFIED
Naranjo, ValeryUNSPECIFIEDorcid.org/0000-0002-0181-3412UNSPECIFIED
Ghosh, SubrataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iacucci, MariettaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-697156
DOI: 10.1136/gutjnl-2021-326376
Journal or Publication Title: Gut
Volume: 71
Number: 5
Page Range: S. 889 - 899
Date: 2022
Publisher: BMJ PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1468-3288
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DISEASE-ACTIVITY; CHROMOENDOSCOPY SCORE; INFLAMMATION; RELAPSE; RELIABILITY; VALIDATION; THERAPY; IMPACTMultiple languages
Gastroenterology & HepatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69715

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item