Brosseron, Frederic ORCID: 0000-0003-3137-7516, Maass, Anne, Kleineidam, Luca, Ravichandran, Kishore Aravind ORCID: 0000-0002-2429-5988, Gonzalez, Pablo Garcia, McManus, Roisin M., Ising, Christina ORCID: 0000-0002-7267-3488, Santarelli, Francesco, Kolbe, Carl-Christian, Haesler, Lisa M., Wolfsgruber, Steffen, Marquie, Marta, Boada, Merce ORCID: 0000-0003-2617-3009, Orellana, Adelina ORCID: 0000-0002-0204-1944, de Rojas, Itziar, Roeske, Sandra, Peters, Oliver ORCID: 0000-0003-0568-2998, Cosma, Nicoleta-Carmen, Cetindag, Arda, Wang, Xiao, Priller, Josef, Spruth, Eike J., Altenstein, Slawek ORCID: 0000-0003-2753-5999, Schneider, Anja ORCID: 0000-0001-9540-8700, Fliessbach, Klaus, Wiltfang, Jens, Schott, Bjorn H., Buerger, Katharina, Janowitz, Daniel, Dichgans, Martin ORCID: 0000-0002-0654-387X, Perneczky, Robert, Rauchmann, Boris-Stephan ORCID: 0000-0003-4547-6240, Teipel, Stefan, Kilimann, Ingo, Goerss, Doreen, Laske, Christoph, Munk, Matthias H., Duzel, Emrah, Yakupov, Renat, Dobisch, Laura, Metzger, Coraline D., Glanz, Wenzel, Ewers, Michael, Dechent, Peter, Haynes, John Dylan, Scheffler, Klaus, Roy, Nina, Rostamzadeh, Ayda ORCID: 0000-0001-5189-134X, Teunissen, Charlotte E., Marchant, Natalie L., Spottke, Annika, Jucker, Mathias, Latz, Eicke ORCID: 0000-0003-1488-5666, Wagner, Michael, Mengel, David, Synofzik, Matthis, Jessen, Frank, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Ruiz, Agustin and Heneka, Michael T. (2022). Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease. Neuron, 110 (6). S. 1009 - 1028. CAMBRIDGE: CELL PRESS. ISSN 1097-4199

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Abstract

There is an urgent need to improve the understanding of neuroinflammation in Alzheimer's disease (AD). We analyzed cerebrospinal fluid inflammatory biomarker correlations to brain structural volume and longitudinal cognitive outcomes in the DELCODE study and in a validation cohort of the F.ACE Alzheimer Center Barcelona. We investigated whether respective biomarker changes are evident before onset of cognitive impairment. YKL-40; sTREM2; sAXL; sTyro3; MIF; complement factors C1q, C4, and H; ferritin; and ApoE protein were elevated in pre-dementia subjects with pathological levels of tau or other neurodegeneration markers, demonstrating tight interactions between inflammation and accumulating neurodegeneration even before onset of symptoms. Intriguingly, higher levels of ApoE and soluble TAM receptors sAXL and sTyro3 were related to larger brain structure and stable cognitive outcome at follow-up. Our findings indicate a protective mechanism relevant for intervention strategies aiming to regulate neuroinflammation in subjects with no or subjective symptoms but underlying AD pathology profile.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Brosseron, FredericUNSPECIFIEDorcid.org/0000-0003-3137-7516UNSPECIFIED
Maass, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleineidam, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ravichandran, Kishore AravindUNSPECIFIEDorcid.org/0000-0002-2429-5988UNSPECIFIED
Gonzalez, Pablo GarciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McManus, Roisin M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ising, ChristinaUNSPECIFIEDorcid.org/0000-0002-7267-3488UNSPECIFIED
Santarelli, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kolbe, Carl-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haesler, Lisa M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marquie, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boada, MerceUNSPECIFIEDorcid.org/0000-0003-2617-3009UNSPECIFIED
Orellana, AdelinaUNSPECIFIEDorcid.org/0000-0002-0204-1944UNSPECIFIED
de Rojas, ItziarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roeske, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDorcid.org/0000-0003-0568-2998UNSPECIFIED
Cosma, Nicoleta-CarmenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cetindag, ArdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, XiaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priller, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spruth, Eike J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altenstein, SlawekUNSPECIFIEDorcid.org/0000-0003-2753-5999UNSPECIFIED
Schneider, AnjaUNSPECIFIEDorcid.org/0000-0001-9540-8700UNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltfang, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schott, Bjorn H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buerger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janowitz, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dichgans, MartinUNSPECIFIEDorcid.org/0000-0002-0654-387XUNSPECIFIED
Perneczky, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauchmann, Boris-StephanUNSPECIFIEDorcid.org/0000-0003-4547-6240UNSPECIFIED
Teipel, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilimann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goerss, DoreenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laske, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munk, Matthias H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duzel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yakupov, RenatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dobisch, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metzger, Coraline D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glanz, WenzelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ewers, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dechent, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haynes, John DylanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheffler, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roy, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rostamzadeh, AydaUNSPECIFIEDorcid.org/0000-0001-5189-134XUNSPECIFIED
Teunissen, Charlotte E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchant, Natalie L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jucker, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Latz, EickeUNSPECIFIEDorcid.org/0000-0003-1488-5666UNSPECIFIED
Wagner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mengel, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Synofzik, MatthisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Ruiz, AgustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heneka, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-697359
DOI: 10.1016/j.neuron.2021.12.016
Journal or Publication Title: Neuron
Volume: 110
Number: 6
Page Range: S. 1009 - 1028
Date: 2022
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1097-4199
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CEREBROSPINAL-FLUID; RISK-FACTORS; BIOMARKERS; MICROGLIA; NEURODEGENERATION; INDIVIDUALS; YKL-40; DETECTMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69735

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