Byonanebye, Dathan M., Polizzotto, Mark N., Neesgaard, Bastian, Sarcletti, Mario, Matulionyte, Raimonda, Braun, Dominique L., Castagna, Antonella, de Wit, Stephane, Wit, Ferdinand, Fontas, Eric, Vehreschild, Joerg Janne, Vesterbacka, Jan, Greenberg, Lauren, Hatleberg, Camilla, Garges, Harmony, Gallant, Joel, Anne, Alain Volny, Oellinger, Angela, Mozer-Lisewska, Iwona, Surial, Bernard ORCID: 0000-0002-1402-974X, Spagnuolo, Vincenzo, Necsoi, Coca, van der Valk, Marc ORCID: 0000-0002-8290-6425, Mocroft, Amanda, Law, Matthew, Ryom, Lene and Petoumenos, Kathy (2022). Incidence of hypertension in people with HIV who are treated with integrase inhibitors versus other antiretroviral regimens in the RESPOND cohort consortium. HIV Med., 23 (8). S. 895 - 911. HOBOKEN: WILEY. ISSN 1468-1293

Full text not available from this repository.

Abstract

Objective To compare the incidence of hypertension in people living with HIV receiving integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) versus non-nucleoside reverse transcriptase inhibitors (NNRTIs) or boosted protease inhibitors (PIs) in the RESPOND consortium of HIV cohorts. Methods Eligible people with HIV were aged >= 18 years who initiated a new three-drug ART regimen for the first time (baseline), did not have hypertension, and had at least two follow-up blood pressure (BP) measurements. Hypertension was defined as two consecutive systolic BP measurements >= 140 mmHg and/or diastolic BP >= 90 mmHg or initiation of antihypertensives. Multivariable Poisson regression was used to determine adjusted incidence rate ratios (aIRRs) of hypertension, overall and in those who were ART naive or experienced at baseline. Results Overall, 4606 people living with HIV were eligible (INSTIs 3164, NNRTIs 807, PIs 635). The median baseline systolic BP, diastolic BP, and age were 120 (interquartile range [IQR] 113-130) mmHg, 78 (70-82) mmHg, and 43 (34-50) years, respectively. Over 8380.4 person-years (median follow-up 1.5 [IQR 1.0-2.7] years), 1058 (23.0%) participants developed hypertension (incidence rate 126.2/1000 person-years, 95% confidence interval [CI] 118.9-134.1). Participants receiving INSTIs had a higher incidence of hypertension than those receiving NNRTIs (aIRR 1.76; 95% CI 1.47-2.11), whereas the incidence was no different in those receiving PIs (aIRR 1.07; 95% CI 0.89-1.29). The results were similar when the analysis was stratified by ART status at baseline. Conclusion Although unmeasured confounding and channelling bias cannot be excluded, INSTIs were associated with a higher incidence of hypertension than were NNRTIs, but rates were similar to those of PIs overall, in ART-naive and ART-experienced participants within RESPOND.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Byonanebye, Dathan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polizzotto, Mark N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neesgaard, BastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarcletti, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matulionyte, RaimondaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun, Dominique L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castagna, AntonellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Wit, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wit, FerdinandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fontas, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Joerg JanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vesterbacka, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greenberg, LaurenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hatleberg, CamillaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garges, HarmonyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallant, JoelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anne, Alain VolnyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oellinger, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mozer-Lisewska, IwonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Surial, BernardUNSPECIFIEDorcid.org/0000-0002-1402-974XUNSPECIFIED
Spagnuolo, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Necsoi, CocaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Valk, MarcUNSPECIFIEDorcid.org/0000-0002-8290-6425UNSPECIFIED
Mocroft, AmandaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Law, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ryom, LeneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petoumenos, KathyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-697371
DOI: 10.1111/hiv.13273
Journal or Publication Title: HIV Med.
Volume: 23
Number: 8
Page Range: S. 895 - 911
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1468-1293
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INCREASED BLOOD-PRESSURE; INFECTED PATIENTS; CLINICAL CARE; THERAPY; RISK; POPULATION; PREVALENCE; PREDICTORS; ADULTS; TIMEMultiple languages
Infectious DiseasesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69737

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item