Moustakis, Christos ORCID: 0000-0002-8879-2350, Blanck, Oliver ORCID: 0000-0003-1391-1308, Chan, Mark Ka Heng, Boda-Heggemann, Judit, Andratschke, Nicolaus, Duma, Marciana-Nona, Albers, Dirk, Baeumer, Christian, Fehr, Roman, Koerber, Stefan A., Schmidhalter, Daniel, Alraun, Manfred, Baus, Wolfgang W., Beckers, Eric, Dierl, Mathias, Droege, Stephan, Tazehmahalleh, Fatemeh Ebrahimi, Fleckenstein, Jens, Guckenberger, Matthias ORCID: 0000-0002-7146-9071, Heinz, Christian, Henkenberens, Christoph, Hennig, Andreas, Koehn, Janett, Kornhuber, Christine, Krieger, Thomas, Loutfi-Krauss, Britta, Mayr, Manfred, Oechsner, Markus, Pfeiler, Tina, Pollul, Gerhard, Schoeffler, Juergen, Tuemmler, Heiko, Ullm, Claudia, Walke, Mathias, Weigel, Rocco, Wertman, Martin, Wiehle, Rolf, Wiezorek, Tilo, Wilke, Lotte ORCID: 0000-0002-0702-2355, Wolf, Ulrich, Eich, Hans Theodor and Schmitt, Daniela (2022). Planning Benchmark Study for Stereotactic Body Radiation Therapy of Liver Metastases: Results of the DEGRO/DGMP Working Group on Stereotactic Radiation Therapy and Radiosurgery. Int. J. Radiat. Oncol. Biol. Phys., 113 (1). S. 214 - 228. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-355X

Full text not available from this repository.

Abstract

Purpose: Our purpose was to investigate whether liver stereotactic body radiation therapy treatment planning can be harmonized across different treatment planning systems, delivery techniques, and institutions by using a specific prescription method and to minimize the knowledge gap concerning intersystem and interuser differences. We provide best practice guidelines for all used techniques. Methods and Materials: A multiparametric specification of target dose (gross target volume [GTV](D50%), GTV(D0.1cc), GTV(V90%), planning target volume [PTV](V70%)) with a prescription dose of GTV(D50% )= 3 x 20 Gy and organ-at-risk (OAR) limits were distributed with computed tomography and structure sets from 3 patients with liver metastases. Thirty-five institutions provided 132 treatment plans using different irradiation techniques. These plans were first analyzed for target and OAR doses. Four different renormalization methods were performed (PTVDmin, PTVD98%, PTVD2% , PTVDmax). The resulting 660 treatments plans were evaluated regarding target doses to study the effect of dose renormalization to different prescription methods. A relative scoring system was used for comparisons. Results: GTV(D50%) prescription can be performed in all systems. Treatment plan harmonization was overall successful, with standard deviations for Dmax, PTVD98%, GTV(D98%), and PTVDmean of 1.6, 3.3, 1.9, and 1.5 Gy, respectively. Primary analysis showed 55 major deviations from clinical goals in 132 plans, whereas in only <20% of deviations GTV/PTV dose was traded for meeting OAR limits. GTV(D50%) prescription produced the smallest deviation from target planning objectives and between techniques, followed by the PTVDmax, PTVD98%, PTVD2%, and PTV(Dmin )prescription. Deviations were significant for all combinations but for the PTVDmax prescription compared with GTV(D50%) and PTVD98%. Based on the various dose prescription methods, all systems significantly differed from each other, whereas GTV(D50%) and PTVD98% prescription showed the least difference between the systems. Conclusions: This study showed the feasibility of harmonizing liver stereotactic body radiation therapy treatment plans across different treatment planning systems and delivery techniques when a sufficient set of clinical goals is given. (C) 2022 Elsevier Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Moustakis, ChristosUNSPECIFIEDorcid.org/0000-0002-8879-2350UNSPECIFIED
Blanck, OliverUNSPECIFIEDorcid.org/0000-0003-1391-1308UNSPECIFIED
Chan, Mark Ka HengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boda-Heggemann, JuditUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andratschke, NicolausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duma, Marciana-NonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Albers, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baeumer, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fehr, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koerber, Stefan A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidhalter, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alraun, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baus, Wolfgang W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beckers, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dierl, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Droege, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tazehmahalleh, Fatemeh EbrahimiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fleckenstein, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guckenberger, MatthiasUNSPECIFIEDorcid.org/0000-0002-7146-9071UNSPECIFIED
Heinz, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henkenberens, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hennig, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehn, JanettUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krieger, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loutfi-Krauss, BrittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayr, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oechsner, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeiler, TinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pollul, GerhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoeffler, JuergenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tuemmler, HeikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ullm, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walke, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weigel, RoccoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wertman, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiehle, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiezorek, TiloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilke, LotteUNSPECIFIEDorcid.org/0000-0002-0702-2355UNSPECIFIED
Wolf, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eich, Hans TheodorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmitt, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-697876
DOI: 10.1016/j.ijrobp.2022.01.008
Journal or Publication Title: Int. J. Radiat. Oncol. Biol. Phys.
Volume: 113
Number: 1
Page Range: S. 214 - 228
Date: 2022
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1879-355X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RADIOTHERAPY; SBRT; PRINCIPLES; GUIDELINESMultiple languages
Oncology; Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69787

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item