Imori, Yoichi, Kato, Ken, Cammann, Victoria L., Szawan, Konrad A., Wischnewsky, Manfred, Dreiding, Sara, Wuerdinger, Michael, Schoenberger, Maximilian, Petkova, Vanya, Niederseer, David, Levinson, Rena A., Di Vece, Davide, Gili, Sebastiano ORCID: 0000-0002-0542-0448, Seifert, Burkhardt, Wakita, Masaki, Suzuki, Noriko, Citro, Rodolfo ORCID: 0000-0002-7796-6298, Bossone, Eduardo, Heiner, Susanne, Knorr, Maike, Jansen, Thomas, Muenzel, Thomas, D'Ascenzo, Fabrizio, Franke, Jennifer, Sorici-Barb, Ioana, Katus, Hugo A., Sarcon, Annahita, Shinbane, Jerold, Napp, L. Christian ORCID: 0000-0001-9945-0842, Bauersachs, Johann, Jaguszewski, Milosz, Shiomura, Reiko, Nakamura, Shunichi, Takano, Hitoshi, Noutsias, Michel, Burgdorf, Christof, Ishibashi, Iwao, Himi, Toshiharu, Koenig, Wolfgang ORCID: 0000-0002-2064-9603, Schunkert, Heribert, Thiele, Holger, Kherad, Behrouz, Tschope, Carsten ORCID: 0000-0001-5243-8985, Pieske, Burkert M., Rajan, Lawrence, Michels, Guido, Pfister, Roman, Mizuno, Shingo, Cuneo, Alessandro ORCID: 0000-0003-1443-2341, Jacobshagen, Claudius, Hasenfuss, Gerd, Karakas, Mahir, Mochizuki, Hiroki, Pott, Alexander, Rottbauer, Wolfgang, Said, Samir M., Braun-Dullaeus, Ruediger C., Banning, Adrian ORCID: 0000-0002-2842-7861, Isogai, Toshiaki, Kimura, Akihisa, Cuculi, Florim, Kobza, Richard ORCID: 0000-0003-3988-7262, Fischer, Thomas A., Vasankari, Tuija, Airaksinen, K. E. Juhani, Tomita, Yasuhiro, Budnik, Monika, Opolski, Grzegorz ORCID: 0000-0003-4744-2554, Dworakowski, Rafal, MacCarthy, Philip, Kaiser, Christoph, Osswald, Stefan ORCID: 0000-0002-9240-6731, Galiuto, Leonarda, Crea, Filippo ORCID: 0000-0002-9482-411X, Dichtl, Wolfgang, Murakami, Tsutomu, Ikari, Yuji, Empen, Klaus, Beug, Daniel, Felix, Stephan B., Delmas, Clement, Lairez, Olivier, Yamaguchi, Tetsuo, El-Battrawy, Ibrahim ORCID: 0000-0002-0139-1045, Akin, Ibrahim, Borggrefe, Martin, Horowitz, John D., Kozel, Martin, Tousek, Petr, Widimsky, Petr ORCID: 0000-0001-5686-7752, Gilyarova, Ekaterina, Shilova, Alexandra, Gilyarov, Mikhail, Neuhaus, Michael, Meyer, Philippe, Arroja, Jose David, Chan, Christina, Bridgman, Paul, Galuszka, Jan, Poglajen, Gregor, Carrilho-Ferreira, Pedro, Pinto, Fausto J., Hauck, Christian, Maier, Lars S., Liu, Kan, Di Mario, Carlo, Paolini, Carla, Bilato, Claudio ORCID: 0000-0003-3474-0579, Bianco, Matteo ORCID: 0000-0002-6751-6437, Joerg, Lucas, Rickli, Hans, Winchester, David E., Ukena, Christian ORCID: 0000-0002-9810-4662, Boehm, Michael, Bax, Jeroen J., Prasad, Abhiram, Rihal, Charanjit S., Saito, Shigeru, Kobayashi, Yoshio, Luscher, Thomas F., Ruschitzka, Frank, Shimizu, Wataru ORCID: 0000-0001-9941-8973, Ghadri, Jelena R. and Templin, Christian (2022). Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry. Clin. Res. Cardiol., 111 (2). S. 186 - 197. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1861-0692

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Abstract

Background Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes. Methods TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients. Results A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 +/- 11.4 years vs. 68.0 +/- 12.0 years; p < 0.001) and more likely to be male (18.5 vs. 8.4%; p< 0.001) than European TTS patients. Physical triggering factors were more common (45.5 vs. 32.0%; p < 0.001), and emotional triggers less common (17.5 vs. 31.5%; p < 0.001), in Japanese patients than in European patients. Japanese patients were more likely to experience cardiogenic shock during the acute phase (15.5 vs. 9.0%; p < 0.001) and had a higher in-hospital mortality (8.2 vs. 3.2%; p< 0.001). However, ethnicity itself did not appear to have an impact on in-hospital mortality. Machine learning approach revealed that the presence of physical stressors was the most important prognostic factor in both Japanese and European TTS patients. Conclusion Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Imori, YoichiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kato, KenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cammann, Victoria L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szawan, Konrad A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wischnewsky, ManfredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreiding, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wuerdinger, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoenberger, MaximilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petkova, VanyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niederseer, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Levinson, Rena A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Di Vece, DavideUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gili, SebastianoUNSPECIFIEDorcid.org/0000-0002-0542-0448UNSPECIFIED
Seifert, BurkhardtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wakita, MasakiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suzuki, NorikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Citro, RodolfoUNSPECIFIEDorcid.org/0000-0002-7796-6298UNSPECIFIED
Bossone, EduardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heiner, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knorr, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansen, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muenzel, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Ascenzo, FabrizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, JenniferUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sorici-Barb, IoanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katus, Hugo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarcon, AnnahitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shinbane, JeroldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Napp, L. ChristianUNSPECIFIEDorcid.org/0000-0001-9945-0842UNSPECIFIED
Bauersachs, JohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaguszewski, MiloszUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shiomura, ReikoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nakamura, ShunichiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Takano, HitoshiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noutsias, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgdorf, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ishibashi, IwaoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Himi, ToshiharuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, WolfgangUNSPECIFIEDorcid.org/0000-0002-2064-9603UNSPECIFIED
Schunkert, HeribertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiele, HolgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kherad, BehrouzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tschope, CarstenUNSPECIFIEDorcid.org/0000-0001-5243-8985UNSPECIFIED
Pieske, Burkert M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rajan, LawrenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michels, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, RomanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mizuno, ShingoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuneo, AlessandroUNSPECIFIEDorcid.org/0000-0003-1443-2341UNSPECIFIED
Jacobshagen, ClaudiusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasenfuss, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karakas, MahirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mochizuki, HirokiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pott, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rottbauer, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Said, Samir M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun-Dullaeus, Ruediger C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Banning, AdrianUNSPECIFIEDorcid.org/0000-0002-2842-7861UNSPECIFIED
Isogai, ToshiakiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kimura, AkihisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuculi, FlorimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobza, RichardUNSPECIFIEDorcid.org/0000-0003-3988-7262UNSPECIFIED
Fischer, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasankari, TuijaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Airaksinen, K. E. JuhaniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomita, YasuhiroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Budnik, MonikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opolski, GrzegorzUNSPECIFIEDorcid.org/0000-0003-4744-2554UNSPECIFIED
Dworakowski, RafalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacCarthy, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osswald, StefanUNSPECIFIEDorcid.org/0000-0002-9240-6731UNSPECIFIED
Galiuto, LeonardaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crea, FilippoUNSPECIFIEDorcid.org/0000-0002-9482-411XUNSPECIFIED
Dichtl, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murakami, TsutomuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ikari, YujiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Empen, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beug, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felix, Stephan B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delmas, ClementUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lairez, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yamaguchi, TetsuoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
El-Battrawy, IbrahimUNSPECIFIEDorcid.org/0000-0002-0139-1045UNSPECIFIED
Akin, IbrahimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Borggrefe, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horowitz, John D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kozel, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tousek, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Widimsky, PetrUNSPECIFIEDorcid.org/0000-0001-5686-7752UNSPECIFIED
Gilyarova, EkaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shilova, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gilyarov, MikhailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhaus, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arroja, Jose DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chan, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bridgman, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galuszka, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poglajen, GregorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carrilho-Ferreira, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinto, Fausto J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hauck, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, Lars S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, KanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Di Mario, CarloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paolini, CarlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bilato, ClaudioUNSPECIFIEDorcid.org/0000-0003-3474-0579UNSPECIFIED
Bianco, MatteoUNSPECIFIEDorcid.org/0000-0002-6751-6437UNSPECIFIED
Joerg, LucasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rickli, HansUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winchester, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ukena, ChristianUNSPECIFIEDorcid.org/0000-0002-9810-4662UNSPECIFIED
Boehm, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bax, Jeroen J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prasad, AbhiramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rihal, Charanjit S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saito, ShigeruUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobayashi, YoshioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luscher, Thomas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruschitzka, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shimizu, WataruUNSPECIFIEDorcid.org/0000-0001-9941-8973UNSPECIFIED
Ghadri, Jelena R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Templin, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699366
DOI: 10.1007/s00392-021-01857-4
Journal or Publication Title: Clin. Res. Cardiol.
Volume: 111
Number: 2
Page Range: S. 186 - 197
Date: 2022
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1861-0692
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
OPERATING CHARACTERISTIC CURVES; IN-HOSPITAL MORTALITY; CARDIOMYOPATHY; DISPARITIES; RISKMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69936

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