Sousa-Pinto, Bernardo ORCID: 0000-0002-1277-3401, Azevedo, Luis Filipe, Sa-Sousa, Ana ORCID: 0000-0002-9429-6863, Vieira, Rafael Jose, Amaral, Rita, Klimek, Ludger, Czarlewski, Wienczyslawa, Anto, Josep M., Bedbrook, Anna, Kvedariene, Violeta, Ventura, Maria Teresa, Ansotegui, Ignacio J., Bergmann, Karl-Christian ORCID: 0000-0002-0306-9922, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo ORCID: 0000-0002-0658-2449, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., De Feo, Giulia, Devillier, Philippe, Fokkens, Wytske J., Gaga, Mina, Gemicioglu, Bilun ORCID: 0000-0001-5953-4881, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor ORCID: 0000-0002-4708-0859, Kraxner, Helga, Larenas-Linnemann, Desiree E., Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo ORCID: 0000-0002-1003-3629, Morais-Almeida, Mario, Moesges, Ralph, Mullol, Joaquim, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna ORCID: 0000-0003-0890-6686, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao Almeida, Bousquet, Jean and Pfaar, Oliver (2022). Allergen immunotherapy in MASK-air users in real-life: Results of a Bayesian mixed-effects model. Clin. Transl. Allergy, 12 (3). HOBOKEN: WILEY. ISSN 2045-7022

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Abstract

Background Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real-life studies. Objective To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK-air(R) app: those receiving sublingual AIT (SLIT), those receiving subcutaneous AIT (SCIT), and those receiving no AIT. Methods We assessed the MASK-air(R) data of European users with self-reported grass pollen allergy, comparing the data reported by patients receiving SLIT, SCIT and no AIT. Outcome variables included the daily impact of allergy symptoms globally and on work (measured by visual analogue scales-VASs), and a combined symptom-medication score (CSMS). We applied Bayesian mixed-effects models, with clustering by patient, country and pollen season. Results We analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT-tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = -12.1;-2.8), lower VAS Work (average difference = 5.0; 95%CrI = -8.5;-1.5), and a lower CSMS (average difference = 3.7; 95%CrI = -9.3;2.2). When compared to SCIT, SLIT-tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = -17.2;-2.8), lower VAS Work (average difference = 7.8; 95%CrI = -15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = -18.5;0.2). Conclusion In patients with grass pollen allergy, SLIT-tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally-harmonised standards for performing and reporting real-world data in AIT are needed to better understand its 'real-world' effectiveness.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sousa-Pinto, BernardoUNSPECIFIEDorcid.org/0000-0002-1277-3401UNSPECIFIED
Azevedo, Luis FilipeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sa-Sousa, AnaUNSPECIFIEDorcid.org/0000-0002-9429-6863UNSPECIFIED
Vieira, Rafael JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amaral, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimek, LudgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Czarlewski, WienczyslawaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anto, Josep M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bedbrook, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kvedariene, VioletaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ventura, Maria TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ansotegui, Ignacio J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergmann, Karl-ChristianUNSPECIFIEDorcid.org/0000-0002-0306-9922UNSPECIFIED
Brussino, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canonica, G. WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cardona, VictoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carreiro-Martins, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Casale, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cecchi, LorenzoUNSPECIFIEDorcid.org/0000-0002-0658-2449UNSPECIFIED
Chivato, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chu, Derek K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cingi, CemalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costa, Elisio M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cruz, Alvaro A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Feo, GiuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devillier, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fokkens, Wytske J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaga, MinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gemicioglu, BilunUNSPECIFIEDorcid.org/0000-0001-5953-4881UNSPECIFIED
Haahtela, TariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ivancevich, Juan CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ispayeva, ZhanatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jutel, MarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuna, PiotrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaidashev, IgorUNSPECIFIEDorcid.org/0000-0002-4708-0859UNSPECIFIED
Kraxner, HelgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Larenas-Linnemann, Desiree E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laune, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lipworth, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Louis, RenaudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Makris, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monti, RiccardoUNSPECIFIEDorcid.org/0000-0002-1003-3629UNSPECIFIED
Morais-Almeida, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moesges, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mullol, JoaquimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Odemyr, MikaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okamoto, YoshitakaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papadopoulos, Nikolaos G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patella, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regateiro, Frederico S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reitsma, SietzeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rouadi, Philip W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samolinski, BoleslawUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sova, MilanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Todo-Bom, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taborda-Barata, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomazic, Peter ValentinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toppila-Salmi, SannaUNSPECIFIEDorcid.org/0000-0003-0890-6686UNSPECIFIED
Sastre, JoaquinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsiligianni, IoannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valiulis, ArunasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wallace, DanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waserman, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yorgancioglu, ArzuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zidarn, MihaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zuberbier, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fonseca, Joao AlmeidaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bousquet, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfaar, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699379
DOI: 10.1002/clt2.12128
Journal or Publication Title: Clin. Transl. Allergy
Volume: 12
Number: 3
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 2045-7022
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
RHINITIS; EFFICACY; ASTHMA; GUIDELINES; IMPACTMultiple languages
AllergyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69937

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