Sousa-Pinto, Bernardo ORCID: 0000-0002-1277-3401, Schunemann, Holger J., Sa-Sousa, Ana, Vieira, Rafael Jose, Amaral, Rita, Anto, Josep M., Klimek, Ludger, Czarlewski, Wienczyslawa, Mullol, Joaquim, Pfaar, Oliver, Bedbrook, Anna, Brussino, Luisa, Kvedariene, Violeta, Larenas-Linnemann, Desiree E., Okamoto, Yoshitaka, Ventura, Maria Teresa, Agache, Ioana, Ansotegui, Ignacio J., Bergmann, Karl C., Bosnic-Anticevich, Sinthia ORCID: 0000-0001-5077-8329, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Thomas, Cecchi, Lorenzo ORCID: 0000-0002-0658-2449, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Del Giacco, Stefano, Devillier, Philippe, Eklund, Patrik, Fokkens, Wytske J., Gemicioglu, Bilun ORCID: 0000-0001-5953-4881, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor ORCID: 0000-0002-4708-0859, Khaitov, Musa, Kraxner, Helga, Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo, Morais-Almeida, Mario, Mosges, Ralph, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Patella, Vincenzo, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sheikh, Aziz, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Toppila-Salmi, Sanna ORCID: 0000-0003-0890-6686, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A. and Bousquet, Jean (2023). Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK-air (R) longitudinal study. Allergy, 78 (4). S. 968 - 984. HOBOKEN: WILEY. ISSN 1398-9995

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Abstract

Introduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air (R), these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air (R) longitudinally, clustering weeks according to reported rhinitis symptoms. Methods: We analyzed MASK-air (R) data, assessing the weeks for which patients had answered a rhinitis daily questionnaire on all 7days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used the latent class mixture model to assess the robustness of results. Results: We analyzed 113,239 days (16,177 complete weeks) from 2590 patients (mean age +/- SD = 39.1 +/- 13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed a higher frequency of rhinitis co-medication, a more frequent change of medication schemes and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control. Conclusions: We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms. [GRAPHICS] .

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sousa-Pinto, BernardoUNSPECIFIEDorcid.org/0000-0002-1277-3401UNSPECIFIED
Schunemann, Holger J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sa-Sousa, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vieira, Rafael JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amaral, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anto, Josep M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimek, LudgerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Czarlewski, WienczyslawaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mullol, JoaquimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfaar, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bedbrook, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brussino, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kvedariene, VioletaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Larenas-Linnemann, Desiree E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okamoto, YoshitakaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ventura, Maria TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agache, IoanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ansotegui, Ignacio J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergmann, Karl C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bosnic-Anticevich, SinthiaUNSPECIFIEDorcid.org/0000-0001-5077-8329UNSPECIFIED
Canonica, G. WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cardona, VictoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carreiro-Martins, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Casale, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cecchi, LorenzoUNSPECIFIEDorcid.org/0000-0002-0658-2449UNSPECIFIED
Chivato, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chu, Derek K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cingi, CemalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costa, Elisio M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cruz, Alvaro A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Del Giacco, StefanoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devillier, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eklund, PatrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fokkens, Wytske J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gemicioglu, BilunUNSPECIFIEDorcid.org/0000-0001-5953-4881UNSPECIFIED
Haahtela, TariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ivancevich, Juan CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ispayeva, ZhanatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jutel, MarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuna, PiotrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaidashev, IgorUNSPECIFIEDorcid.org/0000-0002-4708-0859UNSPECIFIED
Khaitov, MusaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraxner, HelgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laune, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lipworth, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Louis, RenaudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Makris, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monti, RiccardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morais-Almeida, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mosges, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niedoszytko, MarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papadopoulos, Nikolaos G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patella, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regateiro, Frederico S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reitsma, SietzeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rouadi, Philip W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samolinski, BoleslawUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sheikh, AzizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sova, MilanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Todo-Bom, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taborda-Barata, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toppila-Salmi, SannaUNSPECIFIEDorcid.org/0000-0003-0890-6686UNSPECIFIED
Sastre, JoaquinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsiligianni, IoannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valiulis, ArunasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vandenplas, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wallace, DanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waserman, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yorgancioglu, ArzuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zidarn, MihaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zuberbier, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fonseca, Joao A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bousquet, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699492
DOI: 10.1111/all.15574
Journal or Publication Title: Allergy
Volume: 78
Number: 4
Page Range: S. 968 - 984
Date: 2023
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1398-9995
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Allergy; ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69949

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