Universität zu Köln

Brachvogel, Bent ORCID: 0000-0002-3923-0554, Bubb, Kristina ORCID: 0000-0002-8457-0566, Etich, Julia ORCID: 0000-0003-3238-6692, Probst, Kristina, Parashar, Tanvi, Schuetter, Maximilian, Dethloff, Frederik ORCID: 0009-0002-1114-2621, Reincke, Susanna ORCID: 0000-0003-2286-5761, Nolte, Janica L., Krüger, Marcus ORCID: 0000-0002-5846-6941, Schlötzer-Schrehard, Ursula, Nüchel, Julian ORCID: 0000-0002-8126-415X, Demetriades, Constantinos ORCID: 0000-0001-7813-7726, Giavalisco, Patrick ORCID: 0000-0002-4636-1827 and Riemer, Jan ORCID: 0000-0002-7574-8457 (2025). Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging. Science Advances, 11 (16). pp. 1-21. AAAS American Association for the Advancement of Science. ISSN 2375-2548

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Abstract

Dysfunctional mitochondria reverse the TCA cycle to stimulate a profound skeletal aging response.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Brachvogel, Bent UNSPECIFIED https://orcid.org/0000-0002-3923-0554 UNSPECIFIED Bubb, Kristina UNSPECIFIED https://orcid.org/0000-0002-8457-0566 UNSPECIFIED Etich, Julia UNSPECIFIED https://orcid.org/0000-0003-3238-6692 UNSPECIFIED Probst, Kristina UNSPECIFIED UNSPECIFIED UNSPECIFIED Parashar, Tanvi UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuetter, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Dethloff, Frederik UNSPECIFIED https://orcid.org/0009-0002-1114-2621 UNSPECIFIED Reincke, Susanna UNSPECIFIED https://orcid.org/0000-0003-2286-5761 UNSPECIFIED Nolte, Janica L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krüger, Marcus UNSPECIFIED https://orcid.org/0000-0002-5846-6941 UNSPECIFIED Schlötzer-Schrehard, Ursula UNSPECIFIED UNSPECIFIED UNSPECIFIED Nüchel, Julian UNSPECIFIED https://orcid.org/0000-0002-8126-415X UNSPECIFIED Demetriades, Constantinos UNSPECIFIED https://orcid.org/0000-0001-7813-7726 UNSPECIFIED Giavalisco, Patrick UNSPECIFIED https://orcid.org/0000-0002-4636-1827 UNSPECIFIED Riemer, Jan UNSPECIFIED https://orcid.org/0000-0002-7574-8457 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-791535
Identification Number:	10.1126/sciadv.ads1842
Journal or Publication Title:	Science Advances
Volume:	11
Number:	16
Page Range:	pp. 1-21
Date:	18 April 2025
Publisher:	AAAS American Association for the Advancement of Science
ISSN:	2375-2548
Language:	English
Faculty:	Central Institutions / Interdisciplinary Research Centers External institution Faculty of Mathematics and Natural Sciences Faculty of Medicine
Divisions:	Außeruniversitäre Forschungseinrichtungen > MPI for Biology of Ageing CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry Faculty of Medicine > Kinder- und Jugendmedizin > Klinik und Poliklinik für Kinder- und Jugendmedizin Zentrum für Molekulare Medizin
Subjects:	Chemistry and allied sciences Life sciences Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79153