Universität zu Köln

Konitsioti, Agni M. ORCID: 0000-0002-7296-4349, Grajewski, Rafael ORCID: 0000-0001-6489-2982, Schlamann, Mark, Schroeter, Michael ORCID: 0000-0001-8441-4793, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Warnke, Clemens ORCID: 0000-0002-3510-9255 (2025). Successful Natalizumab Treatment of Two Female Individuals With Susac Syndrome. European Journal of Neurology, 32 (3). pp. 1-7. Wiley. ISSN 1351-5101

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Abstract

Background: Susac syndrome is a rare autoimmune endotheliopathy that affects the central nervous system, retina, and inner ear, characterized by encephalopathy, branch retinal artery occlusions, and sensorineural hearing loss. Due to the heterogeneity of its presentation, early diagnosis, and treatment remain challenging. Objective/Methods: To evaluate the clinical outcomes and radiological responses in two patients with Susac syndrome treated with natalizumab in an off‐label therapeutic approach, clinical assessments and serial magnetic resonance imaging (MRI) were performed over a follow‐up period of up to 22 months to monitor disease progression and treatment response. Results: Both patients demonstrated clinical stabilization with reduced MRI and retinal angiography disease activity. Treatment was well tolerated, and no significant adverse events were reported during observation. Discussion: Natalizumab may constitute a potential off‐label therapeutic for Susac syndrome. Further studies are warranted to assess its efficacy and safety in this rare condition.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Konitsioti, Agni M. UNSPECIFIED https://orcid.org/0000-0002-7296-4349 UNSPECIFIED Grajewski, Rafael UNSPECIFIED https://orcid.org/0000-0001-6489-2982 UNSPECIFIED Schlamann, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, Michael UNSPECIFIED https://orcid.org/0000-0001-8441-4793 UNSPECIFIED Fink, Gereon R. UNSPECIFIED https://orcid.org/0000-0002-8230-1856 UNSPECIFIED Warnke, Clemens UNSPECIFIED https://orcid.org/0000-0002-3510-9255 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-791564
Identification Number:	10.1111/ENE.70103
Journal or Publication Title:	European Journal of Neurology
Volume:	32
Number:	3
Page Range:	pp. 1-7
Date:	3 March 2025
Publisher:	Wiley
ISSN:	1351-5101
Language:	English
Faculty:	External institution Faculty of Medicine
Divisions:	Außeruniversitäre Forschungseinrichtungen > Forschungszentrum Jülich Faculty of Medicine > Augenheilkunde > Klinik und Poliklinik für Allgemeine Augenheilkunde Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie Faculty of Medicine > Radiologische Diagnostik > Institut und Poliklinik für Radiologische Diagnostik
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79156