Universität zu Köln

Dzialas, Verena ORCID: 0000-0001-7226-6674, Bischof, Gérard N., Möllenhoff, Kathrin, Drzezga, Alexander and van Eimeren, Thilo (2025). Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease. Annals of Neurology, 98 (1). pp. 120-135. Wiley. ISSN 0364-5134

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Abstract

Objective: Although dopamine transporter (DaT) imaging is a valuable diagnostic biomarker, few studies have investigated its utility in objectively monitoring disease progression in patients with Parkinson's disease (PD). To date, no study has established a longitudinal relationship between the DaT signal decline and the motor symptom increase, potentially due to neglected factors such as brain regions, disease laterality, and symptom subtypes, which this study addresses. Methods: This cohort study included participants who met the Movement Disorder Society (MDS) criteria for PD, with longitudinal imaging and clinical data from the Parkinson's Progression Markers Initiative Database. Linear mixed model analyses were used to investigate the relationship between the DaT signal decline and the motor symptom severity increase over time. We hypothesized that a decline in putaminal DaT availability in the less affected hemisphere would be associated with increasing contralateral motor symptoms, measured by the Unified Parkinson's Disease Rating Scale (UPDRS). Additional models explored the effects of different brain regions (caudate and putamen), symptom categories (MDS UPDRSIII score with and without tremor items), and disease onset laterality (left or right hemisphere). Results: We included 719 participants (443 male patients and 276 female patients; mean age = 62.2 ± 9.5 years) with 1,981 available data points. As hypothesized, we observed a significant association between the decrease in the less affected putaminal DaT signal and motor symptom increase in the contralateral body side, independent of including or excluding tremor scores. Interpretation: Our findings support the use of repetitive DaT imaging for objectively monitoring PD progression. This could facilitate personalized disease tracking, subtyping, and intervention testing in the future. ANN NEUROL 2025;98:120–135

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Dzialas, Verena UNSPECIFIED https://orcid.org/0000-0001-7226-6674 UNSPECIFIED Bischof, Gérard N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Möllenhoff, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-794405
Identification Number:	10.1002/ana.27223
Journal or Publication Title:	Annals of Neurology
Volume:	98
Number:	1
Page Range:	pp. 120-135
Number of Pages:	16
Date:	27 July 2025
Publisher:	Wiley
ISSN:	0364-5134
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Nuklearmedizin > Klinik und Poliklinik für Nuklearmedizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79440