Universität zu Köln

von Stein, Philipp ORCID: 0000-0003-4548-3897 and Iliadis, Christos ORCID: 0000-0001-7655-8500 (2025). Transcatheter edge-to-edge repair for mitral regurgitation. Trends in Cardiovascular Medicine, 35 (5). pp. 320-325. Elsevier. ISSN 1050-1738

PDF 1-s2.0-S1050173825000258-main.pdf Bereitstellung unter der CC-Lizenz: Creative Commons Attribution Non-commercial No Derivatives. Download (519kB)

Abstract

Mitral valve transcatheter edge-to-edge repair (M-TEER) has emerged as a transformative therapy for mitral regurgitation (MR), addressing the unmet needs of patients unsuitable for surgery. Landmark trials such as EVEREST II, COAPT, and MITRA-FR have established the safety and efficacy of M-TEER, in both patients with primary (PMR) and secondary MR (SMR). Recent trials, including RESHAPE-HF2 and MATTERHORN, have expanded our understanding and refueled discussions regarding patient selection and appropriate treatment indications in SMR. These trials have also contributed to the discussion regarding SMR phenotypes most appropriate for M-TEER. This review summarizes the evidence from pivotal trials, discusses patient selection, device advancements, potential future directions, and outlines ongoing trials that may shape future clinical practice.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code von Stein, Philipp UNSPECIFIED https://orcid.org/0000-0003-4548-3897 UNSPECIFIED Iliadis, Christos UNSPECIFIED https://orcid.org/0000-0001-7655-8500 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-794517
Identification Number:	10.1016/j.tcm.2025.02.004
Journal or Publication Title:	Trends in Cardiovascular Medicine
Volume:	35
Number:	5
Page Range:	pp. 320-325
Number of Pages:	6
Date:	July 2025
Publisher:	Elsevier
ISSN:	1050-1738
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik III für Innere Medizin - Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79451