Universität zu Köln

Kramer, Mira ORCID: 0009-0001-3464-0802, Rosenkranz, Stephan ORCID: 0000-0001-6237-1470 and Kramer, Tilmann ORCID: 0000-0003-0265-7607 (2025). Depression in Pulmonary Hypertension: A Systematic Review of Clinical Outcomes, Treatment Interactions, and Emerging Technologies. Journal of Clinical Medicine, 14 (3). MDPI. ISSN 2077-0383

PDF jcm-14-00982.pdf Bereitstellung unter der CC-Lizenz: Creative Commons Attribution. Download (770kB)

Abstract

[Artikel-Nr. 982] Background: Pulmonary hypertension (PH) is characterized by elevated pulmonary artery pressure, often leading to right heart failure and poor prognosis. Depression, a common comorbidity in PH, significantly affects the quality of life. However, mechanistic insights into the bidirectional relationship between PH and depression and specific treatment interactions remain scarce. Objective: The object was to examine the clinical and therapeutic implications of depression in PH, focusing on its impact on patient outcomes and cost efficiency. Methods: A systematic review of Medline and Google Scholar was conducted to identify studies on depression in PH, emphasizing evidence-based interventions, clinical outcomes, and cost efficiency. Special consideration was given to potential drug interactions between PH medications and depression treatments and to the role of emerging technologies in managing PH-related depression. Results: While depression reduces the quality of life and exacerbates disease severity in PH, depression treatment improves outcomes, particularly when tailored to PH-targeted therapies, considering potential drug–drug interactions. Emerging technologies, including telemedicine, offer innovative approaches to manage depression in PH, enhancing access to care and improving adherence to treatment regimens. Conclusions: Depression in PH must no longer be neglected and should be acknowledged as both a critical comorbidity and a significant driver of disease progression. Interdisciplinary treatment approaches are necessary, considering potential pharmacological interactions and incorporating emerging technologies like telemedicine to improve patient care. Further research is needed to assess the long-term outcomes of depression treatment in different groups of PH.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Kramer, Mira UNSPECIFIED https://orcid.org/0009-0001-3464-0802 UNSPECIFIED Rosenkranz, Stephan UNSPECIFIED https://orcid.org/0000-0001-6237-1470 UNSPECIFIED Kramer, Tilmann UNSPECIFIED https://orcid.org/0000-0003-0265-7607 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-796561
Identification Number:	10.3390/jcm14030982
Journal or Publication Title:	Journal of Clinical Medicine
Volume:	14
Number:	3
Number of Pages:	1
Date:	4 February 2025
Publisher:	MDPI
ISSN:	2077-0383
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik III für Innere Medizin - Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79656