Universität zu Köln

Dapper, Hendrik ORCID: 0009-0005-8041-3634, Rudroff, Claudia, Linde, Philipp ORCID: 0000-0002-2813-1331, Rosenbrock, Johannes ORCID: 0000-0003-3340-0556, Schmitz, Joel, Ferdinandus, Simone, Jablonska, Karolina, Martin, Daniel, Rödel, Claus and Fokas, Emmanouil ORCID: 0000-0003-1601-6165 (2025). Radiation therapy in anal high-grade squamous intraepithelial lesions—a pattern of care analysis in German-speaking countries. Strahlentherapie und Onkologie, 201 (7). pp. 699-705. Springer Nature. ISSN 0179-7158

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Abstract

Background: High-grade squamous intraepithelial lesions (HSIL) of the anal region are recognized as precursor lesions to squamous cell carcinoma of the anus (SCCA), especially in individuals infected with the human papillomavirus (HPV). Although recent studies indicate that treating HSIL can reduce progression to SCCA, optimal management strategies remain undefined. High recurrence rates and treatment-associated morbidities underscore the need for effective therapeutic options. Methods: A survey among radiation oncologists in Germany was conducted between September and October 2024, covering clinical practice settings, the frequency of HSIL cases, experience with radiotherapy, reasons for radiotherapy inquiries, treatment indications, and concurrent therapies. Results: A total of 58 radiation oncologists participated in the survey, with 37 (63.8%) reporting inquiries about radiotherapy for HSIL, primarily for patients with multiple recurrences. Radiotherapy was generally considered an appropriate option, particularly for recurrent cases where other treatments posed risks, especially complications or worsening of anorectal function after local excision. However, only half of the respondents (29) had prior experience with treating anal HSIL and rated radiotherapy outcomes as good or very good. Most respondents indicated a preference for treating only the local area (i.e., excluding lymphatic drainage pathways) to a total dose of 40–50 Gy. Conclusion: Recurrent anal HSIL presents a major challenge for patients, with no established effective treatment standards available. Radiotherapy is frequently requested and administered, showing promising preliminary outcomes. Clinical studies are warranted to evaluate the effectiveness and tolerability of radiotherapy in patients with anal HSIL.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Dapper, Hendrik UNSPECIFIED https://orcid.org/0009-0005-8041-3634 UNSPECIFIED Rudroff, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Linde, Philipp UNSPECIFIED https://orcid.org/0000-0002-2813-1331 UNSPECIFIED Rosenbrock, Johannes UNSPECIFIED https://orcid.org/0000-0003-3340-0556 UNSPECIFIED Schmitz, Joel UNSPECIFIED UNSPECIFIED UNSPECIFIED Ferdinandus, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Jablonska, Karolina UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Rödel, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Fokas, Emmanouil UNSPECIFIED https://orcid.org/0000-0003-1601-6165 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-797896
Identification Number:	10.1007/s00066-025-02380-5
Journal or Publication Title:	Strahlentherapie und Onkologie
Volume:	201
Number:	7
Page Range:	pp. 699-705
Number of Pages:	7
Date:	7 July 2025
Publisher:	Springer Nature
ISSN:	0179-7158
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Strahlentherapie > Klinik und Poliklinik für Radioonkologie, Cyberknife- und Strahlentherapie
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79789