Universität zu Köln

Cimen, Cansu ORCID: 0000-0002-6136-5252, Siemer, Philipp, Sattler, Janko ORCID: 0000-0003-1415-4169, Voss, Andreas, Berends, Matthijs S., Hamprecht, Axel ORCID: 0000-0003-1449-5780 and Simner, Patricia J. (2025). Performance of disk diffusion, gradient test, and VITEK 2 for carbapenem susceptibility testing in OXA-48-like carbapenemase-producing Enterobacterales: a comparative study. Journal of Clinical Microbiology, 63 (5). pp. 1-12. ASM American Society for Microbiology. ISSN 0095-1137

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Abstract

[Artikel-Nr. e01893-24] OXA-48-like is the most frequent carbapenemase in western Europe, and both its rapid spread and its challenging-to-detect nature are a particular concern for adequate treatment and infection control purposes. Accurate determination of carbapenem minimal inhibitory concentrations (MICs) is of utmost importance, both for the selection of the best therapy and as a marker for carbapenemase detection. However, the performance of derivative susceptibility testing methods is unclear for OXA-48-like isolates. Our study reports on the varying performance of carbapenem susceptibility testing by disk diffusion, gradient test (ETEST), and VITEK 2 in OXA-48-like-producing Enterobacterales . The results of the present study can help to inform about the limitations of current susceptibility testing methods and serve to improve MIC determination in these challenging isolates.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Cimen, Cansu UNSPECIFIED https://orcid.org/0000-0002-6136-5252 UNSPECIFIED Siemer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Sattler, Janko UNSPECIFIED https://orcid.org/0000-0003-1415-4169 UNSPECIFIED Voss, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Berends, Matthijs S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamprecht, Axel UNSPECIFIED https://orcid.org/0000-0003-1449-5780 UNSPECIFIED Simner, Patricia J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-799797
Identification Number:	10.1128/jcm.01893-24
Journal or Publication Title:	Journal of Clinical Microbiology
Volume:	63
Number:	5
Page Range:	pp. 1-12
Date:	14 May 2025
Publisher:	ASM American Society for Microbiology
ISSN:	0095-1137
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Medizinische Mikrobiologie, Immunologie und Hygiene > Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language carbapenemase, OXA-48-like, carbapenem, antibiotic susceptibility testing, minimum inhibitory concentration, broth microdilution, gradient test, ETEST, disk diffusion, VITEK English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/79979