Schomäcker, Klaus 
ORCID: 0000-0003-2636-0058, Fischer, Thomas ORCID: 0000-0001-6118-5182, Sudbrock, Ferdinand, Strohe, Daniela, Weber, Sebastian, Zimmermanns, Beate ORCID: 0009-0009-2207-9657, Dietlein, Felix, Krapf, Philipp ORCID: 0000-0003-1671-2443, Schicha, Harald, Dietlein, Markus ORCID: 0000-0003-0992-6099 and Drzezga, Alexander ORCID: 0000-0001-6018-716X
(2025).
Radioiodine Exhalation Following Oral I-131 Administration in a Mouse Model.
Biomedicines, 13 (4).
pp. 1-17.
MDPI.
ISSN 2227-9059
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Abstract
[Artikel-Nr. 897] Background: The exhalation of radioiodine following radioiodine therapy (RIT) presents a challenge in radiation protection, though the mechanisms remain incompletely understood. Previous studies have indicated that radioiodine is predominantly exhaled in an organically bound form in humans. Methods: This study investigates the chemical composition and exhaled amounts of radioiodine, as well as the impact of thyroid-targeted pharmacological interventions, using a controlled mouse model. Female Balb/c mice (25 g) were administered oral doses of radioiodine (0.1, 1, 2, 10, and 23 MBq per animal) with and without prior treatment using thyroid-blocking agents (stable iodine, perchlorate) or antithyroid drugs (carbimazole). Exhaled radioiodine was collected in metabolic cages, separating chemical forms (aerosolized iodine, elemental iodine, organically bound iodine), and quantified via scintillation counter. Results: The exhaled radioiodine activity was proportional to the administered dose (0.2–0.3%). Thyroid-blocking agents increased exhalation, shifting toward elemental iodine. Antithyroid drugs reduced exhalation but increased aerosol formation, particularly at higher I-131 doses. Organically bound iodine remained the predominant exhaled species in all groups. Conclusions: These results highlight the critical role of the thyroid in radioiodine organification. The blockade of thyroid uptake disrupted the formation of organically bound iodine, suggesting that iodine organification requires passage through the thyroid. Additionally, the results support the hypothesis that iodine metabolism outside the thyroid is less efficient, contributing to the formation of organic iodine species. Radical formation is likely a key factor in generating these volatile iodine species, with radiation-induced iodine and methyl radicals playing a role in their formation.
| Item Type: | Article |
| Creators: | Creators Email ORCID ORCID Put Code Sudbrock, Ferdinand UNSPECIFIED UNSPECIFIED UNSPECIFIED Strohe, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Schicha, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED |
| URN: | urn:nbn:de:hbz:38-799881 |
| Identification Number: | 10.3390/biomedicines13040897 |
| Journal or Publication Title: | Biomedicines |
| Volume: | 13 |
| Number: | 4 |
| Page Range: | pp. 1-17 |
| Number of Pages: | 1 |
| Date: | 8 April 2025 |
| Publisher: | MDPI |
| ISSN: | 2227-9059 |
| Language: | English |
| Faculty: | Central Institutions / Interdisciplinary Research Centers Faculty of Medicine |
| Divisions: | Außeruniversitäre Forschungseinrichtungen > Forschungszentrum Jülich Faculty of Medicine > Nuklearmedizin > Klinik und Poliklinik für Nuklearmedizin |
| Subjects: | Medical sciences Medicine |
| Uncontrolled Keywords: | Keywords Language iodine-131; exhalation; radioiodine therapy English |
| ['eprint_fieldname_oa_funders' not defined]: | Publikationsfonds UzK |
| Refereed: | Yes |
| URI: | http://kups.ub.uni-koeln.de/id/eprint/79988 |
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