Universität zu Köln

Cao, Mengyang ORCID: 0009-0002-5660-7074, Todorov, Plamen ORCID: 0000-0003-3731-6116, Rahimi, Gohar, Salama, Mahmoud ORCID: 0000-0002-0282-8018, Woodruff, Teresa K. ORCID: 0000-0002-1197-3399, Isachenko, Evgenia ORCID: 0000-0003-2542-3408, Skala, Christine and Isachenko, Volodimir ORCID: 0000-0002-3674-543X (2025). Construction and Bioengineering of Human Bioprosthetic Ovaries from Cryopreserved Ovarian Tissue. International Journal of Molecular Sciences, 26 (12). MDPI. ISSN 1422-0067

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Abstract

[Artikel-Nr.: 5545] Ovarian tissue cryopreservation is increasingly recognized as an effective fertility preservation option for cancer patients undergoing gonadotoxic therapies. After cancer treatment, transplantation of frozen–thawed ovarian tissue can restore both fertility and endocrine function. However, the threat of reintroducing malignant cells limits its application in patients with a high risk of ovarian metastasis. To eliminate potential cancer cells in grafts, a promising strategy involves isolating follicles from cryopreserved ovarian tissue and encapsulating them within biocompatible scaffolds to construct transplantable bioprosthetic ovaries. Here, we review the construction of bioprosthetic ovaries designed to mimic natural ovarian architecture, and further discuss the challenges in bioprosthetic ovary bioengineering along with potential strategies to address these issues.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Cao, Mengyang UNSPECIFIED https://orcid.org/0009-0002-5660-7074 UNSPECIFIED Todorov, Plamen UNSPECIFIED https://orcid.org/0000-0003-3731-6116 UNSPECIFIED Rahimi, Gohar UNSPECIFIED UNSPECIFIED UNSPECIFIED Salama, Mahmoud UNSPECIFIED https://orcid.org/0000-0002-0282-8018 UNSPECIFIED Woodruff, Teresa K. UNSPECIFIED https://orcid.org/0000-0002-1197-3399 UNSPECIFIED Isachenko, Evgenia UNSPECIFIED https://orcid.org/0000-0003-2542-3408 UNSPECIFIED Skala, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Isachenko, Volodimir UNSPECIFIED https://orcid.org/0000-0002-3674-543X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-800037
Identification Number:	10.3390/ijms26125545
Journal or Publication Title:	International Journal of Molecular Sciences
Volume:	26
Number:	12
Number of Pages:	22
Date:	10 June 2025
Publisher:	MDPI
ISSN:	1422-0067
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Frauenheilkunde > Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language ovarian tissue cryopreservation ; bioprosthetic ovaries ; follicle loss ; revascularization ; scaffolds English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80003