Universität zu Köln

Werra, Ursula E. M. ORCID: 0000-0003-3334-7708, Ahmad, Wael ORCID: 0000-0001-5090-3468, Schoepal, Michael, Trinh, Tran T. and Dorweiler, Bernhard ORCID: 0000-0002-8262-8381 (2025). Intraoperative Application of Cold Atmospheric Plasma Reduces Inguinal Wound Healing Disorders—A Pilot Study. Journal of Clinical Medicine, 14 (21). MDPI. ISSN 2077-0383

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Abstract

[Artikel-Nr.: 7533] Background: Inguinal wound healing disorders have been a relevant problem in the surgical treatment of peripheral arterial occlusive disease (PAD) for decades with reported rates of up to 30%. Despite the otherwise diverse innovations in vascular surgery, there are hardly any improvements in this area, on the contrary, comorbidities such as obesity, as relevant risk factors, continue to increase. The application of cold atmospheric plasma (CAP) has in turn shown promise in approaches for the treatment of chronic wounds, we therefore evaluated the potential reduction in inguinal wound healing disorders through the intraoperative application of CAP. Methods: We carried out a pilot study including 50 patients with a high risk for inguinal wound healing disorders that underwent a peripheral arterial reconstruction with inguinal access. Alternately, these patients were treated once intraoperatively with CAP (n = 25) or served as the control group (n = 25). The wound condition was then evaluated for the next fourteen days, with a follow up of three months. Results: The two groups showed no differences regarding risk factors such as smoking, obesity, PAD stage or surgery-related aspects like incision length or duration of surgery. No differences were found regarding wound-related readmission. However, the patients who had been treated intraoperatively with CAP showed a significant reduction in the need for surgical revisions due to inguinal wound healing disorders (8% vs. 32%, p = 0.034). Conclusions: This pilot study shows that the intraoperative use of CAP could be a promising approach to reduce major inguinal wound healing disorders.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Werra, Ursula E. M. UNSPECIFIED https://orcid.org/0000-0003-3334-7708 UNSPECIFIED Ahmad, Wael UNSPECIFIED https://orcid.org/0000-0001-5090-3468 UNSPECIFIED Schoepal, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Trinh, Tran T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dorweiler, Bernhard UNSPECIFIED https://orcid.org/0000-0002-8262-8381 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-800762
Identification Number:	10.3390/jcm14217533
Journal or Publication Title:	Journal of Clinical Medicine
Volume:	14
Number:	21
Number of Pages:	12
Date:	24 October 2025
Publisher:	MDPI
ISSN:	2077-0383
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Chirurgie > Klinik und Poliklinik für Gefäßchirurgie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language cold plasma ; surgical site infection ; intraoperative care ; vascular surgery ; wound revision ; high-risk patients English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80076