Universität zu Köln

Rose, France ORCID: 0000-0001-5828-3259, Ibruli, Olta, Lichius, Luca, Kiljan, Martha ORCID: 0000-0002-5581-1359, Gozum, Gokcen ORCID: 0000-0002-8650-0078, Caiaffa, Manoela Iannicelli ORCID: 0009-0007-0704-0397, Cai, Jiali ORCID: 0009-0009-5976-0235, Niu, Li-na ORCID: 0000-0002-6653-0819, Herter, Jan M., Grüll, Holger ORCID: 0000-0002-0993-9300, Büttner, Reinhard ORCID: 0000-0001-8806-4786, Beleggia, Filippo ORCID: 0000-0003-0234-7094, Bosco, Graziella ORCID: 0000-0001-6601-4518, George, Julie ORCID: 0000-0002-4272-3683, Herter-Sprie, Grit S., Reinhardt, Hans Christian and Bozek, Katarzyna ORCID: 0000-0002-0917-6876 (2025). Imaging mass cytometry dataset of small-cell lung cancer tumors and tumor microenvironments. BMC Research Notes, 18 (1). pp. 1-4. Springer Nature. ISSN 1756-0500

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Abstract

[Artikel-Nr.: 385] Objectives: Small cell lung cancer (SCLC) accounts for approximately 15% of lung tumors and is marked by aggressive growth and early metastatic spread. In this study, we used two SCLC mouse models with differing tumor mutation burdens (TMB). To investigate tumor composition, spatial architecture, and interactions with the surrounding microenvironment, we acquired multiplexed images of mouse lung tumors using imaging mass cytometry (IMC). These data build upon a previously published characterization of the mouse model. Data description: After tumor detection, mice were assigned to one of five treatment groups. Lung tumor tissues were imaged with a 37-marker IMC panel designed to identify major cell types—tumor, immune, and structural—as well as their functional states. When possible, each tumor was sampled both at its center and border regions. Tumor masks in the form of binary images are provided to delineate tumor areas. Additional metadata include tumor onset and endpoint dates to support downstream correlation or predictive analyses based on the image data. This dataset offers a valuable resource for studying the histological and cellular complexity of SCLC in a genetically controlled mouse model across multiple therapeutic conditions.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Rose, France UNSPECIFIED https://orcid.org/0000-0001-5828-3259 UNSPECIFIED Ibruli, Olta ibruliolta@gmail.com UNSPECIFIED UNSPECIFIED Lichius, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiljan, Martha UNSPECIFIED https://orcid.org/0000-0002-5581-1359 UNSPECIFIED Gozum, Gokcen UNSPECIFIED https://orcid.org/0000-0002-8650-0078 UNSPECIFIED Caiaffa, Manoela Iannicelli UNSPECIFIED https://orcid.org/0009-0007-0704-0397 UNSPECIFIED Cai, Jiali UNSPECIFIED https://orcid.org/0009-0009-5976-0235 UNSPECIFIED Niu, Li-na UNSPECIFIED https://orcid.org/0000-0002-6653-0819 UNSPECIFIED Herter, Jan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grüll, Holger UNSPECIFIED https://orcid.org/0000-0002-0993-9300 UNSPECIFIED Büttner, Reinhard UNSPECIFIED https://orcid.org/0000-0001-8806-4786 UNSPECIFIED Beleggia, Filippo UNSPECIFIED https://orcid.org/0000-0003-0234-7094 UNSPECIFIED Bosco, Graziella UNSPECIFIED https://orcid.org/0000-0001-6601-4518 UNSPECIFIED George, Julie UNSPECIFIED https://orcid.org/0000-0002-4272-3683 UNSPECIFIED Herter-Sprie, Grit S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinhardt, Hans Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Bozek, Katarzyna UNSPECIFIED https://orcid.org/0000-0002-0917-6876 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-801324
Identification Number:	10.1186/s13104-025-07460-4
Journal or Publication Title:	BMC Research Notes
Volume:	18
Number:	1
Page Range:	pp. 1-4
Number of Pages:	4
Date:	8 September 2025
Publisher:	Springer Nature
ISSN:	1756-0500
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Hals-Nasen-Ohrenheilkunde > Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Pathologie und Neuropathologie > Institut für Pathologie Faculty of Medicine > Strahlentherapie > Klinik und Poliklinik für Radioonkologie, Cyberknife- und Strahlentherapie Faculty of Medicine > Weitere > Institut für Biomedizinische Informatik Faculty of Medicine > Weitere > Translationale Genomik Zentrum für Molekulare Medizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language SCLC ; IMC ; MIBI-TOF ; Hyperion ; Tumor microenvironment ; Mouse models English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80132