Universität zu Köln

Klaus, Johannes ORCID: 0009-0003-9837-5758, Gerhardt, Felix ORCID: 0009-0002-3249-5493, Nienaber, Stephan ORCID: 0000-0001-5779-7549, Mauri, Victor ORCID: 0000-0003-2678-3501, Möllenhoff, Kathrin ORCID: 0000-0001-7861-3892, Nies, Richard ORCID: 0000-0002-1336-6031, Kuhn, Elmar ORCID: 0000-0001-6301-7422, Gerfer, Stephen ORCID: 0000-0002-6568-6766, Djordjevic, Ilija ORCID: 0000-0002-5810-8626, Lee, Samuel ORCID: 0000-0001-6768-7079, Guthoff, Henning ORCID: 0000-0002-0979-1190, Iliadis, Christos ORCID: 0000-0001-7655-8500, Baldus, Stephan ORCID: 0000-0001-8259-1737, Hohmann, Christopher ORCID: 0000-0003-2821-4134, Adam, Matti ORCID: 0000-0002-6990-8135 and Wienemann, Hendrik ORCID: 0000-0001-5810-2868 (2025). Safety and effectiveness of oscillatory whole-body vibration training on exercise capacity and physical performance in aortic valve stenosis patients prior to transcatheter aortic valve implantation: a randomized clinical trial. Clinical Research in Cardiology, 114. pp. 1-13. Springer Nature. ISSN 1861-0684

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Abstract

Background: Exercise training is generally discouraged in patients with severe symptomatic aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) due to safety concerns. However, whole-body vibration (WBV) exercise could offer a novel approach to improve exercise capacity and quality of life, though its effects remain unclear in this population. Methods: Thirty patients with AS scheduled for TAVI were prospectively and randomly assigned to either the WBV group (12 sessions, 30 min each over 4 weeks) or a control group. Assessments of cardiopulmonary exercise testing (CPET), 6-min walking distance (6MWD) and health-related quality of life (HRQoL) questionnaires were conducted at baseline (V1), one day before TAVI (V2) and at short-term follow-up (V3). WBV was conducted between V1 and V2. Results: For the analysis at V1 and V2 16 patients in the WBV group and 14 in the control group were included. Mean age was 79.7 ± 5.22 years, with a mean aortic valve area of 0.75 ± 0.21 cm 2 . Peak V’O 2 increased by 0.3 mL*min -1 *kg -1 in the WBV group versus a decrease of − 1.4 mL*min -1 *kg -1 in the control group (difference, 1.7 mL*min -1 *kg -1 ; 95% CI, [0.2 to 3.2], p = 0.03). Peak power improved by 5.1 W in the WBV group compared to a decline of − 4.5 W in the control group (difference, 9.6 W; 95% CI, [2.1 to 17.1], p = 0.01). The WBV group also showed a non-significant improvement in 6MWD (34 m vs. − 8 m in the control group; difference, 42 m; 95% CI, [-10 to 93], p = 0.11). No serious adverse events occurred in the WBV group. Conclusion: This pilot study demonstrated that a WBV exercise program is feasible, safe, and showed potential to preserve exercise capacity as well as physical performance in AS patients scheduled for TAVI.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Klaus, Johannes UNSPECIFIED https://orcid.org/0009-0003-9837-5758 UNSPECIFIED Gerhardt, Felix UNSPECIFIED https://orcid.org/0009-0002-3249-5493 UNSPECIFIED Nienaber, Stephan UNSPECIFIED https://orcid.org/0000-0001-5779-7549 UNSPECIFIED Mauri, Victor UNSPECIFIED https://orcid.org/0000-0003-2678-3501 UNSPECIFIED Möllenhoff, Kathrin UNSPECIFIED https://orcid.org/0000-0001-7861-3892 UNSPECIFIED Nies, Richard UNSPECIFIED https://orcid.org/0000-0002-1336-6031 UNSPECIFIED Kuhn, Elmar UNSPECIFIED https://orcid.org/0000-0001-6301-7422 UNSPECIFIED Gerfer, Stephen UNSPECIFIED https://orcid.org/0000-0002-6568-6766 UNSPECIFIED Djordjevic, Ilija UNSPECIFIED https://orcid.org/0000-0002-5810-8626 UNSPECIFIED Lee, Samuel UNSPECIFIED https://orcid.org/0000-0001-6768-7079 UNSPECIFIED Guthoff, Henning UNSPECIFIED https://orcid.org/0000-0002-0979-1190 UNSPECIFIED Iliadis, Christos UNSPECIFIED https://orcid.org/0000-0001-7655-8500 UNSPECIFIED Baldus, Stephan UNSPECIFIED https://orcid.org/0000-0001-8259-1737 UNSPECIFIED Hohmann, Christopher UNSPECIFIED https://orcid.org/0000-0003-2821-4134 UNSPECIFIED Adam, Matti UNSPECIFIED https://orcid.org/0000-0002-6990-8135 UNSPECIFIED Wienemann, Hendrik UNSPECIFIED https://orcid.org/0000-0001-5810-2868 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-801862
Identification Number:	10.1007/s00392-025-02744-y
Journal or Publication Title:	Clinical Research in Cardiology
Volume:	114
Page Range:	pp. 1-13
Number of Pages:	13
Date:	22 September 2025
Publisher:	Springer Nature
ISSN:	1861-0684
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik III für Innere Medizin - Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Transcatheter aortic valve implantation ; Aortic valve stenosis ; Peak V’O2 ; Endurance capacity ; Oscillatory ; whole-body vibration English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80186