Universität zu Köln

Bröckelmann, Paul J. ORCID: 0000-0001-9662-9900, Scheffer Cliff, Edward R., Iacoboni, Gloria, Simon, Florian ORCID: 0000-0002-2700-3717, Horowitz, Mary M., Keating, Armand, Mateos, Maria-Victoria, Mohty, Mohamad, Sidana, Surbhi, Song, Yuqin, Wingard, John R. and Thanarajasingam, Gita (2025). Beyond maximum grade: tolerability of immunotherapies, cellular therapies, and targeted agents in haematological malignancies. The Lancet Haematology, 12 (6). e470-e481. Elsevier. ISSN 2352-3026

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Abstract

The increasing use of immunotherapeutic approaches, cellular therapies, and targeted agents is rapidly and profoundly changing the treatment paradigms of haematological malignancies. These novel therapies are increasingly incorporated into earlier lines of treatment. Some are administered for a fixed duration, often with curative intent, whereas others are administered chronically for disease control. The associated acute, mid-term, and long-term toxic effects can differ markedly from conventional cytotoxic chemotherapy and radiotherapy. Accumulating clinical experience and data enable identification of class-specific effects and development of consensus-based guidelines for toxicity management. In this third paper in the Series on adverse event reporting, we build on our emerging understanding of toxicity profiles of novel treatments to propose an actionable framework for improved assessment, reporting, and critical appraisal of treatment tolerability. We discuss recent insights regarding second cancers and the relevance of infectious complications, explore tolerability aspects of time-limited treatments, and suggest approaches to address gaps in tolerability assessment.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Bröckelmann, Paul J. UNSPECIFIED https://orcid.org/0000-0001-9662-9900 UNSPECIFIED Scheffer Cliff, Edward R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Iacoboni, Gloria UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Florian UNSPECIFIED https://orcid.org/0000-0002-2700-3717 UNSPECIFIED Horowitz, Mary M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Keating, Armand UNSPECIFIED UNSPECIFIED UNSPECIFIED Mateos, Maria-Victoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohty, Mohamad UNSPECIFIED UNSPECIFIED UNSPECIFIED Sidana, Surbhi UNSPECIFIED UNSPECIFIED UNSPECIFIED Song, Yuqin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wingard, John R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thanarajasingam, Gita UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-802148
Identification Number:	10.1016/S2352-3026(25)00051-1
Journal or Publication Title:	The Lancet Haematology
Volume:	12
Number:	6
Page Range:	e470-e481
Number of Pages:	12
Date:	June 2025
Publisher:	Elsevier
ISSN:	2352-3026
Language:	English
Faculty:	Central Institutions / Interdisciplinary Research Centers Faculty of Medicine
Divisions:	Außeruniversitäre Forschungseinrichtungen > MPI for Biology of Ageing Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Weitere > Centrum für integrierte Onkologie (CIO)
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80214