Universität zu Köln

Kleineberg, Nina N. ORCID: 0000-0003-2582-878X, Schmidt, Claudia C. ORCID: 0000-0002-1296-577X, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Weiss, Peter H. ORCID: 0000-0002-5230-9080 (2025). Differential Lesion Patterns Associated With Stroke‐Induced Apraxia in Women and Men. European Journal of Neurology, 32 (5). pp. 1-10. Wiley. ISSN 1351-5101

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Abstract

[Artikel-Nr.: e70201] Background: The motor‐cognitive syndrome apraxia is a common stroke sequela and severely affects the outcome after stroke by impairing activities of daily living. Notably, like in many health conditions, there is a massive backlog regarding studies on sex differences in patients with apraxia despite common knowledge that sex influences praxis performance in healthy participants. We investigated putative sex differences in apraxic stroke patients at the behavioral and neural levels. Methods: We retrospectively analysed the data of a cohort of 102 left‐hemisphere stroke patients in the (sub)acute phase who were apraxic according to the Cologne Apraxia Screening (KAS). We conducted voxel‐based lesion–symptom mapping (VLSM) to elucidate the lesion patterns. Further, in an age‐matched subsample (tolerance of 5 years) with equal numbers of men and women, behavioral comparisons and a VLSM analysis were conducted to explore differential sex‐related lesion patterns. Results: Overall, apraxic deficits were associated with lesions in the parietal, temporal, and frontal regions in the cohort of 102 left‐hemisphere stroke patients. The age‐matched cohort consisted of 30 women and 30 men and showed no significant differences in demographic and clinical characteristics. There were no performance differences between men and women at the behavioral level regarding praxis functions. In contrast, VLSM revealed differential lesion patterns by sex. Male compared to female apraxic stroke patients significantly more often showed lesions that affected the left inferior frontal gyrus. Conclusion: The data suggest a differential organization of the praxis system in men and women, warranting further exploration.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Kleineberg, Nina N. UNSPECIFIED https://orcid.org/0000-0003-2582-878X UNSPECIFIED Schmidt, Claudia C. UNSPECIFIED https://orcid.org/0000-0002-1296-577X UNSPECIFIED Fink, Gereon R. UNSPECIFIED https://orcid.org/0000-0002-8230-1856 UNSPECIFIED Weiss, Peter H. UNSPECIFIED https://orcid.org/0000-0002-5230-9080 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-802820
Identification Number:	10.1111/ENE.70201
Journal or Publication Title:	European Journal of Neurology
Volume:	32
Number:	5
Page Range:	pp. 1-10
Number of Pages:	10
Date:	23 May 2025
Publisher:	Wiley
ISSN:	1351-5101
Language:	English
Faculty:	Faculty of Medicine External institution
Divisions:	Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie Außeruniversitäre Forschungseinrichtungen > Forschungszentrum Jülich
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language gender ; imitation ; pantomime ; sex differences ; voxel-based lesion–symptom mapping (VLSM) English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80282