Universität zu Köln

Salmanton-García, Jon ORCID: 0000-0002-6766-8297, Giacinta, Alessandro, Giannella, Maddalena, Vena, Antonio, Muñoz, Patricia, Cornely, Oliver A. ORCID: 0000-0001-9599-3137 and Valerio, Maricela (2025). Current trends on antifungal prophylaxis in solid organ transplantation: a study from ESCMID-EFISG, ESCMID-ESGICH, SITA, and SEIMC-GESITRA-IC. Infection, 53 (6). pp. 2411-2420. Springer Nature. ISSN 0300-8126

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Abstract

Introduction: Invasive fungal diseases (IFD) present serious risks to solid organ transplant recipients, particularly in the first 180 days post-transplant. Existing European and US guidelines offer limited evidence, prompting a shift away from universal prophylaxis due to adverse effects, drug-interactions, and costs. This study investigates antifungal prophylaxis practices in transplant centers to guide IFD management. Methods: From May 2023 to May 2024, tertiary care institutions completed an online survey on antifungal prophylaxis post- transplant. Data included transplant volumes, IFD incidence by pathogen, and prophylactic strategies. Results Responses from 64 centers in 32 countries, mainly in Europe, highlighted kidney and liver as the most common transplants. Prophylaxis was universal in lung transplants and common in liver, bowel, and heart transplants, often triggered by reintervention or Candida spp. colonization. Preferred agents included liposomal amphotericin B and fluconazole. Conclusions: This global survey reveals substantial variation in antifungal prophylaxis practices among solid organ transplant centers, driven by a lack of standardized, evidence-based guidelines. Our findings underscore the urgent need for harmonized recommendations that reflect evolving fungal epidemiology, improved diagnostics, and new antifungal agents.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Salmanton-García, Jon UNSPECIFIED https://orcid.org/0000-0002-6766-8297 UNSPECIFIED Giacinta, Alessandro UNSPECIFIED UNSPECIFIED UNSPECIFIED Giannella, Maddalena UNSPECIFIED UNSPECIFIED UNSPECIFIED Vena, Antonio UNSPECIFIED UNSPECIFIED UNSPECIFIED Muñoz, Patricia UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver A. UNSPECIFIED https://orcid.org/0000-0001-9599-3137 UNSPECIFIED Valerio, Maricela UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-803389
Identification Number:	10.1007/s15010-025-02575-z
Journal or Publication Title:	Infection
Volume:	53
Number:	6
Page Range:	pp. 2411-2420
Number of Pages:	10
Date:	4 December 2025
Publisher:	Springer Nature
ISSN:	0300-8126
Language:	English
Faculty:	Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Weitere > Centrum für integrierte Onkologie (CIO) Faculty of Medicine > Weitere > Zentrum für Klinische Studien Zentrum für Molekulare Medizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Invasive fungal diseases ; Solid organ transplant ; Antifungal ; Prophylaxis ; Fungal epidemiology ; Biomarker ; Breakthrough IFD English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80338