Universität zu Köln

Lindau, Simone and Steinbicker, Andrea U. ORCID: 0000-0002-5237-961X (2025). Blood transfusion and patient blood management in cancer patients. Best Practice & Research Clinical Anaesthesiology, 39 (1). pp. 50-56. Elsevier. ISSN 1753-3740

PDF 1-s2.0-S152168962500028X-main.pdf Bereitstellung unter der CC-Lizenz: Creative Commons Attribution. Download (522kB)

Abstract

Anemia is common in cancer patients and linked to higher mortality, longer hospital stays, and reduced survival. Iron deficiency and the second most common form of anemia, anemia of chronic disease caused by elevated hepcidin levels, limit iron availability. Although red blood cell (RBC = transfusions quickly raise hemoglobin levels, they are associated with increased risks of tumor recurrence, infections, and reduced cancer-specific survival. Intravenous iron therapy and/or erythropoiesis-stimulating agents (ESAs) are effective alternatives to manage anemia. Patient Blood Management (PBM) offers a structured strategy to reduce transfusions by multiple ap- proaches such as preoperative iron therapy, restrictive transfusion strategy and conserving blood during surgery. Clinical studies have shown that PBM significantly reduced transfusion rates, lowered infection risks, and shortened hospital stays without compromising safety. An individ- ualized therapeutic approach seems beneficial in oncologic patients.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Lindau, Simone UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinbicker, Andrea U. UNSPECIFIED https://orcid.org/0000-0002-5237-961X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-804906
Identification Number:	10.1016/j.bpa.2025.04.004
Journal or Publication Title:	Best Practice & Research Clinical Anaesthesiology
Volume:	39
Number:	1
Page Range:	pp. 50-56
Number of Pages:	7
Date:	1 March 2025
Publisher:	Elsevier
ISSN:	1753-3740
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Anästhesiologie und Operative Intensivmedizin > Klinik für Anästhesiologie und Operative Intensivmedizin
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Cancer patients ; Iron deficiency anemia ; Anemia of inflammation ; Anemia treatment ; Red blood cell transfusion ; Patient blood management English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80490