Universität zu Köln

Fang, Xiaofeng, May, Alexander I., Sporbeck, Katharina, Hauer, Lukas ORCID: 0000-0003-1893-2124 and Knorr, Roland L. ORCID: 0000-0002-6747-0088 (2025). Wet scissors. How biomolecular condensates cut cellular membranes. Current Opinion in Plant Biology, 86. pp. 1-7. Elsevier. ISSN 1369-5266

PDF 1-s2.0-S1369526625000548-main.pdf Bereitstellung unter der CC-Lizenz: Creative Commons Attribution. Download (1MB)

Abstract

[Artikel-Nr.: 102740] Membrane shape is a fundamental determinant of cellular organisation. Reshaping of membranes is crucial for dynamic processes including organelle and cell division, endocytosis and membrane trafficking. Membrane fission (or scission) is a discontinuous, topological shape change that is central in many such processes. Specialised remodelling proteins, such as dynamins and ESCRT proteins, are capable of forming oligomeric spirals that drive membrane fission in cells. In this review, we summarise evidence demonstrating that capillary forces generated by liquid-like biomolecular condensates can facilitate cellular membrane reshaping and drive fission events. We draw on our recent findings that condensates are implicated in multivesicular body formation to describe the molecular and physical principles that allow biomolecular condensates to cut membranes. We further discuss possible interactions between novel condensate-mediated fission processes and established reshaping processes. We propose that condensates make an important contribution to membrane remodelling events involved in the biogenesis of diverse cellular structures. The characterisation of condensate-mediated membrane reshaping promises to transform our understanding of intracellular organisation and dynamics.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Fang, Xiaofeng UNSPECIFIED UNSPECIFIED UNSPECIFIED May, Alexander I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sporbeck, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hauer, Lukas UNSPECIFIED https://orcid.org/0000-0003-1893-2124 UNSPECIFIED Knorr, Roland L. UNSPECIFIED https://orcid.org/0000-0002-6747-0088 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-804988
Identification Number:	10.1016/j.pbi.2025.102740
Journal or Publication Title:	Current Opinion in Plant Biology
Volume:	86
Page Range:	pp. 1-7
Number of Pages:	7
Date:	August 2025
Publisher:	Elsevier
ISSN:	1369-5266
Language:	English
Faculty:	Faculty of Medicine
Divisions:	CECAD - Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases Faculty of Medicine > Biochemie > Zentrum für Biochemie
Subjects:	Medical sciences Medicine
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80498