Universität zu Köln

Borchmann, Peter ORCID: 0000-0003-3782-2158, Eichenauer, Dennis A. ORCID: 0000-0002-1927-3514, Frigola, Gerard and Campo, Elias (2025). Nodular Lymphocyte‐Predominant Hodgkin Lymphoma: Update on Biology and Treatment. Hematological Oncology, 43 (S2). pp. 1-6. Wiley. ISSN 0278-0232

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Abstract

[Artikel-Nr.: e70080] Nodular lymphocyte‐predominant B‐cell/Hodgkin lymphoma (NLPB/HL) accounts for roughly 5% of all Hodgkin lymphoma (HL) cases. In contrast to classic HL (cHL), the malignant cells in NLPB/HL lack CD30 expression but maintain a complete phenotype of mature B‐cells including CD20 and IgG, but occasionally show IgD expression. The tumor cells are known as lymphocyte‐predominant (LP) cells and grow in a T‐cell and histiocyte rich microenvironment against a background of follicular dendritic cells. Transformation to large B cell lymphoma may occur and requires excisional lymph node biopsies. Most patients with NLPB/HL present in early stages. The disease usually has an indolent clinical course. Approaches applied in cHL result in very good outcomes with only limited excess mortality in comparison with the general population. Activity has also been demonstrated for rituximab‐containing regimens commonly used in indolent B‐cell non‐Hodgkin lymphoma. The present article reviews pathological characteristics, treatment options and tools that might improve risk stratification in NLPB/HL.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Borchmann, Peter UNSPECIFIED https://orcid.org/0000-0003-3782-2158 UNSPECIFIED Eichenauer, Dennis A. UNSPECIFIED https://orcid.org/0000-0002-1927-3514 UNSPECIFIED Frigola, Gerard UNSPECIFIED UNSPECIFIED UNSPECIFIED Campo, Elias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-805217
Identification Number:	10.1002/hon.70080
Journal or Publication Title:	Hematological Oncology
Volume:	43
Number:	S2
Page Range:	pp. 1-6
Number of Pages:	6
Date:	15 June 2025
Publisher:	Wiley
ISSN:	0278-0232
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Innere Medizin > Klinik I für Innere Medizin - Hämatologie und Onkologie Faculty of Medicine > Weitere > Centrum für integrierte Onkologie (CIO)
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Hodgkin lymphoma ; immuno‐architectural patterns ; lymphoma transformation ; nodular lymphocyte‐predominant B‐cell/Hodgkin lymphoma ; T‐cell and histiocyte reach large B‐cell lymphoma English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80521