Universität zu Köln

Isachenko, Volodimir ORCID: 0000-0002-3674-543X, Morgenstern, Bernd ORCID: 0000-0002-5689-0079, Todorov, Plamen, Isachenko, Evgenia ORCID: 0000-0003-2542-3408, Nawroth, Frank, Quassdorff, Maria, Salama, Mahmoud, Mallmann-Gottschalk, Nina, Merzenich, Markus, Skala, Christine ORCID: 0000-0003-0282-8840 and Rahimi, Gohar (2025). Cryopreservation and transplantation of ovarian tissue as post-cancer tissue therapy and an activator of oogenesis. Journal of Ovarian Research, 18 (1). pp. 1-4. Springer Nature. ISSN 1757-2215

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Abstract

In a recent publication (Reprod. Biomed. Online, 2024) it was presented point of view that, for post-cancer patients, in vitro fertilization (IVF) is a more effective method than ovarian tissue cryopreservation (OTC). In their commentary, Andersen et al. (Reprod. Biomed. Online, 2024) present nine distinct arguments advocating for the use of OTC. We fully agree with all these points. In support of the clinical application of the OTC procedure, we introduce two additional arguments. First, the transplantation of cryopreserved ovarian tissue can be considered as a form of tissue therapy. Moreover, OTC inherently serves as an activator of oogenesis. Second, during tissue dissection prior to OTC, a significant number of germinal vesicle (GV) oocytes can be retrieved, matured to the metaphase II (MII) stage, cryopreserved, and later used in IVF procedures.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Isachenko, Volodimir UNSPECIFIED https://orcid.org/0000-0002-3674-543X UNSPECIFIED Morgenstern, Bernd UNSPECIFIED https://orcid.org/0000-0002-5689-0079 UNSPECIFIED Todorov, Plamen UNSPECIFIED UNSPECIFIED UNSPECIFIED Isachenko, Evgenia UNSPECIFIED https://orcid.org/0000-0003-2542-3408 UNSPECIFIED Nawroth, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Quassdorff, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Salama, Mahmoud UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann-Gottschalk, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Merzenich, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Skala, Christine UNSPECIFIED https://orcid.org/0000-0003-0282-8840 UNSPECIFIED Rahimi, Gohar UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-805332
Identification Number:	10.1186/s13048-025-01680-9
Journal or Publication Title:	Journal of Ovarian Research
Volume:	18
Number:	1
Page Range:	pp. 1-4
Number of Pages:	4
Date:	10 June 2025
Publisher:	Springer Nature
ISSN:	1757-2215
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Frauenheilkunde > Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Ovarian tissue cryopreservation ; GV oocyte maturation ; Hippo signaling disruption ; Hypoxia ; Intracellular Ca²⁺ increase English Osmotic disruption of cellular membranes ; Reactive oxygen species (ROS) generation ; Lipid peroxidation English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80533