Universität zu Köln

Yao, Mingchen, Nagamori, Akira, Campos Maçãs, Sandrina ORCID: 0000-0003-4853-3554, Azim, Eiman ORCID: 0000-0002-1015-1772, Sharpee, Tatyana, Goulding, Martyn, Golomb, David and Gatto, Graziana ORCID: 0000-0002-4244-8925 (2025). The spinal premotor network driving scratching flexor and extensor alternation. Cell Reports, 44 (6). pp. 1-24. Elsevier. ISSN 2211-1247

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Abstract

[Artikel-Nr.: 115845] Rhythmic motor behaviors are generated by neural networks termed central pattern generators (CPGs). Although locomotor CPGs have been extensively characterized, it remains unknown how the neuronal pop- ulations composing them interact to generate adaptive rhythms in mammals. We explored the cooperation dynamics among the three main populations of ipsilaterally projecting spinal CPG neurons—V1, V2a, and V2b neurons—in scratch reflex rhythmogenesis. Individual ablation of the three neuronal populations reduced the oscillation frequency. Activation of excitatory V2a neurons enhanced the oscillation frequency, while acti- vating inhibitory V1 neurons suppressed movement. Building on these findings, we developed a neurome- chanical model made of self-oscillating flexor and extensor modules coupled via inhibition. Rhythm fre- quency is increased by strong intra-module inhibition and facilitation mechanisms in excitatory neurons and decreased by strong inter-module inhibition. In sum, we describe how genetically identified neuron types and the strengths of their synaptic connections drive scratch rhythmogenesis.

Item Type:	Article
Creators:	Creators Email ORCID ORCID Put Code Yao, Mingchen UNSPECIFIED UNSPECIFIED UNSPECIFIED Nagamori, Akira UNSPECIFIED UNSPECIFIED UNSPECIFIED Campos Maçãs, Sandrina UNSPECIFIED https://orcid.org/0000-0003-4853-3554 UNSPECIFIED Azim, Eiman UNSPECIFIED https://orcid.org/0000-0002-1015-1772 UNSPECIFIED Sharpee, Tatyana UNSPECIFIED UNSPECIFIED UNSPECIFIED Goulding, Martyn UNSPECIFIED UNSPECIFIED UNSPECIFIED Golomb, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Gatto, Graziana UNSPECIFIED https://orcid.org/0000-0002-4244-8925 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-805481
Identification Number:	10.1016/j.celrep.2025.115845
Journal or Publication Title:	Cell Reports
Volume:	44
Number:	6
Page Range:	pp. 1-24
Number of Pages:	24
Date:	June 2025
Publisher:	Elsevier
ISSN:	2211-1247
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Neurologie > Klinik und Poliklinik für Neurologie
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language rhythmogenesis English spinal cord circuits English reflexes English sensorimotor responses English CPGs English inhibition English modeling English neuronal perturbations English UNSPECIFIED English
['eprint_fieldname_oa_funders' not defined]:	Publikationsfonds UzK
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/80548